A1388

Adenosine 5′-[γ-thio]triphosphate tetralithium salt

≥75% (HPLC), powder

• Synonim(y): ATP-γ-S, Adenosine 5′-(3-thiotriphosphate) tetralithium salt, Ado-5′-PPP[S]
• Wzór empiryczny (zapis Hilla): C₁₀H₁₂Li₄N₅O₁₂P₃S
• Numer CAS: 93839-89-5
• Masa cząsteczkowa: 546.98
• Beilstein: 6265083
• Numer WE: 298-862-8
• Numer MDL: MFCD00077293
• Kod UNSPSC: 41106305
• eCl@ss: 32160414
• Identyfikator substancji w PubChem: 24890536
• NACRES: NA.51

Właściwości

• pochodzenie biologiczne: synthetic (organic)
• Próba: ≥75% (HPLC)
• Postać: powder
• kolor: off-white
• rozpuszczalność: H₂O: 25 mg/mL
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• ciąg SMILES: [Li+].[Li+].[Li+].[Li+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O
• InChI: 1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1
• Klucz InChI: DWQFDOIBOYDYKH-KWIZKVQNSA-J

Opis

Zastosowanie

Adenosine 5′-[γ-thio]triphosphate tetralithium salt has been used to treat the pollen grains to determine the inhibitory effect of adenosine triphosphate (ATP) or its hydrolysis product. It has also been used to select thiophosphorylate target protein.

Działania biochem./fizjol.

Adenosine 5′-[γ-thio]triphosphate (ATP-γ-S) is widely used as a non-hydrolyzed ATP analogue for studies on the effects of ATP binding to ATP sites in a wide range of processes including extracellular functions. ATP- γ-S is a P2 purinergic agonist which increases the activity of Ca²⁺-activated K⁺ channels. ATP- γ-S can substitute for ATP in kinase reactions yielding thiophosphorylated proteins that are resistant to protein phosphatases and modulate the ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome. ATP-γ -S differentially modulates Toll-like receptor 4-mediated cell survival and death.

Inne uwagi

Non-hydrolyzable ATP analog

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Gloves