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A0604
Monoclonal Anti-Angiopoietin-1 antibody produced in mouse
clone 171718, purified immunoglobulin
Synonim(y):
Anti-ANG-1
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About This Item
Polecane produkty
pochodzenie biologiczne
mouse
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
171718, monoclonal
reaktywność gatunkowa
human
metody
immunohistochemistry: 25 μg/mL using cells and tissue sections
indirect ELISA: 0.5-1.0 μg/mL
western blot: 1-2 μg/mL
izotyp
IgG2b
numer dostępu UniProt
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... ANGPT1(284)
Powiązane kategorie
Opis ogólny
Anti-Angiopoietin-1 detects recombinant human angiopoietin-1. The antibody shows no cross-reactivity with recombinant human angiopoietin-2, recombinant human angiopoietin-4, recombinant mouse angiopoietin-like 3, and recombinant human cornea-derived transcript 6 (CDT-6).The ANG-1 gene is mapped to human chromosome 8q23.1.
Immunogen
purified, NSO-derived, recombinant human ANG-1.
Zastosowanie
Anti-Angiopoietin-1 antibody may be used for immunoblotting at a working concentration of 1-2 μg/mL. It has also been used for immunoblotting using skeletal muscle, kidney, lung, epididymal fat and brain tissue of mouse. For ELISA, the recommended concentration is 0.5-1.0 μg/mL. The antibody is suitable for immunohistochemistry at a working antibody concentration of 25 μg/mL.Monoclonal Anti-Angiopoietin-1 antibody produced in mouse has been used in Western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
Działania biochem./fizjol.
Angiopoietin 1 is an endothelial cell-specific protein that is a ligand for the TIE2 tyrosine receptor. It is required for mature blood vessel formation .
Angiopoietins are growth factors vital for vascular differentiation during normal development. There are four angiopoietins discovered that bind to receptor tyrosine kinases Tie2. Angiopoietin-1 (ANG-1) is a potent pro-angiogenic factor that works by recruits mural cells for endothelial tubule formation and vessel maturation. ANG-1 acts along with VEGF in enhance angiogenesis and increase vascular branching. ANG-1 also affects the inflammatory process and inhibits the capillary transmigration of leukocytes on TNF-α stimulation. Sonic hedgehog, a secreted growth factor, reportedly upregulates the expression of ANG-1. Overexpression of angiopoietins has been observed in a variety of malignancies including neuroblastoma, glioblastoma and lung cancers. While ANG-2 increases the metastasis and angiogenesis of the tumors, ANG-1 inhibits tumor angiogenesis
Angiopoietins are growth factors vital for vascular differentiation during normal development. There are four angiopoietins discovered that bind to receptor tyrosine kinases Tie2. Angiopoietin-1 (ANG-1) is a potent pro-angiogenic factor that works by recruits mural cells for endothelial tubule formation and vessel maturation. ANG-1 acts along with VEGF in enhance angiogenesis and increase vascular branching. ANG-1 also affects the inflammatory process and inhibits the capillary transmigration of leukocytes on TNF-α stimulation. Sonic hedgehog, a secreted growth factor, reportedly upregulates the expression of ANG-1. Overexpression of angiopoietins has been observed in a variety of malignancies including neuroblastoma, glioblastoma and lung cancers. While ANG-2 increases the metastasis and angiogenesis of the tumors, ANG-1 inhibits tumor angiogenesis
Postać fizyczna
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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polecane
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Analysis of Tie receptor tyrosine kinase in haemopoietic progenitor and leukaemia cells.
Kukk E, et al.
British Journal of Haematology, 98(1), 195-203 (1997)
Integrin binding angiopoietin-1 monomers reduce cardiac hypertrophy.
Dallabrida S M, et al.
Faseb Journal, 22(8), 3010-3023 (2008)
Carlo Ricciardi et al.
Biosensors & bioelectronics, 26(4), 1565-1570 (2010-09-17)
Microcantilever based oscillators have shown the possibility of highly sensitive label-free detection by allowing the transduction of a target mass into a resonant frequency shift. Most of such measurements were performed in air or vacuum environment, since immersion in liquid
Xiaochen He et al.
Journal of molecular and cellular cardiology, 112, 104-113 (2017-09-25)
Endothelial glycolysis plays a critical role in the regulation of angiogenesis. We investigated the role of Sirtuin 3 (SIRT3) on endothelial cell (EC) glycolytic metabolism, angiogenesis, and diastolic function. Our aim was to test the hypothesis that loss of SIRT3
S A Ahmad et al.
Cancer research, 61(4), 1255-1259 (2001-03-14)
Angiopoietin (Ang) 1 and Ang-2 are important regulators of endothelial cell survival. Current models suggest that an increase in Ang-2 expression in endothelial cells leads to initiation of angiogenesis. We stably transfected HT29 colon cancer cells with cDNA constructs for
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