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44583

Sigma-Aldrich

Doxorubicin hydrochloride

suitable for fluorescence, 98.0-102.0% (HPLC)

Synonim(y):

DOX, Hydroxydaunorubicin hydrochloride

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About This Item

Wzór empiryczny (zapis Hilla):
C27H29NO11 · HCl
Numer CAS:
25316-40-9
Masa cząsteczkowa:
579.98
Beilstein:
4229251
Numer WE:
246-818-3
Numer MDL:
MFCD00077757
Kod UNSPSC:
51281818
Identyfikator substancji w PubChem:
57650234
NACRES:
NA.76

pochodzenie biologiczne

synthetic

Poziom jakości

200

Próba

98.0-102.0% (HPLC)

Postać

solid

kolor

orange to dark red

mp

216 °C (dec.) (lit.)

rozpuszczalność

H2O: 50 mg/mL, clear, orange to red
DMSO: soluble
THF: soluble
ethanol: soluble
methanol: soluble

fluorescencja

λem 580-590 nm

przydatność

suitable for fluorescence

spektrum działania antybiotyku

neoplastics

Tryb działania

DNA synthesis | interferes
enzyme | inhibits

temp. przechowywania

2-8°C

ciąg SMILES

Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO

InChI

1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

Klucz InChI

MWWSFMDVAYGXBV-RUELKSSGSA-N

informacje o genach

human ... TOP2A(7153)

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Opis ogólny

Chemical structure: tetracycline

Zastosowanie

Doxorubicin was used to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells . It is used to inhibit macromolecular biosynthesis.

Działania biochem./fizjol.

Doxorubicin ia an antitumor antibiotic that intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent .

Opakowanie

Bottomless glass bottle. Contents are inside inserted fused cone.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place.
This page may contain text that has been machine translated.

Piktogramy

Health hazardExclamation mark
GHS08,GHS07

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H302,H340,H350,H360FD

Zwroty wskazujące środki ostrożności

P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405

Klasyfikacja zagrożeń

Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B

Kod klasy składowania

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

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Sigma-Aldrich

T7402

Paclitaxel

Daunorubicin hydrochloride European Pharmacopoeia (EP) Reference Standard

D0125000

Daunorubicin hydrochloride

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Sigma-Aldrich

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Paclitaxel

R L Momparler et al.
Cancer research, 36(8), 2891-2895 (1976-08-01)
The effect of adriamycin on DNA, RNA, and protein synthesis was investigated in cell-free systems and intact cells. In studies with purified mammalian cell enzymes, adriamycin produced a greater inhibition of DNA-dependent DNA polymerase than of RNA polymerase. The extent
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Two new guaianolides, named chinensiolides D (5) and E (6), were isolated from Ixeris chinensis Nakai, and their structures were determined to be 10alpha-hydroxy-3-oxoguaia-11(13)-eno-12,6alpha-lactone (5) and 10alpha-hydroxy-3beta-O-[2,6-di(p-hydroxyphenylacetyl)-beta-glucopylanosyl]guaia-4(15),11(13)-dieno-12,6alpha-lactone (6). The first isolation of (11S)-10alpha-hydroxy-3-oxoguaia-4-eno-12,6alpha-lactone (4) from natural sources and its characterization
C Main et al.
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