402OA-05A
Human Chondrocytes - Osteoarthritis: HC-OA, adult
Synonim(y):
HC-OA cells
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About This Item
Kod UNSPSC:
41106514
NACRES:
NA.81
Polecane produkty
pochodzenie biologiczne
human articular cartilage (osteoarthritic)
Poziom jakości
opakowanie
pkg of 500,000 cells
producent / nazwa handlowa
Cell Applications, Inc
tryb wzrostu
Adherent
kariotyp
2n = 46
morfologia
chondrocyte
metody
cell culture | mammalian: suitable
powiązane choroby
arthritis
Warunki transportu
dry ice
temp. przechowywania
−196°C
Opis ogólny
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HC-OA Human Chondrocytes are derived from human articular cartilage of donors with osteoarthritis (OA). Osteoarthritis is an inflammatory disease characterized by increased degradation of cartilage tissue in the joint due to overproduction of enzymes degrading the extracellular matrix. Despite the initial proliferation and activation of chondrocytes, they are not able to efficiently repair the degrading cartilage. Instead, chondrocytes undergo terminal differentiation and eventually apoptose, leading to mineralization of cartilage in a process resembling bone formation during development. Thus, HC-OA provide a useful model to study changes in chondrocyte biology in response to abnormal environment of the OA joint.
Characterization: Positive for aggrecan after differentiation.
HC-OA have been used to demonstrate that THF-alpha activates transcription of ADAMTS-4, a metalloproteinase implicated in cartilage degradation in OA, via p38-MAPK-dependent mechanism (Xue, 2013).
HC-OA Human Chondrocytes are derived from human articular cartilage of donors with osteoarthritis (OA). Osteoarthritis is an inflammatory disease characterized by increased degradation of cartilage tissue in the joint due to overproduction of enzymes degrading the extracellular matrix. Despite the initial proliferation and activation of chondrocytes, they are not able to efficiently repair the degrading cartilage. Instead, chondrocytes undergo terminal differentiation and eventually apoptose, leading to mineralization of cartilage in a process resembling bone formation during development. Thus, HC-OA provide a useful model to study changes in chondrocyte biology in response to abnormal environment of the OA joint.
Characterization: Positive for aggrecan after differentiation.
HC-OA have been used to demonstrate that THF-alpha activates transcription of ADAMTS-4, a metalloproteinase implicated in cartilage degradation in OA, via p38-MAPK-dependent mechanism (Xue, 2013).
Pochodzenie linii komórkowej
Cartilage
Zastosowanie
model for studying chondrocyte biology in an osteoarthritis joint
Komponenty
Basal Medium containing 10% FBS & 10% DMSO
Uwaga dotycząca przygotowania
- 1st passage, >500,000 cells in Basal Medium containing 10% FBS & 10% DMSO
- Can be cultured at least 10 doublings
Rutyna subkultury
Please refer to the HC-OA Culture Protocol.
Oświadczenie o zrzeczeniu się odpowiedzialności
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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International journal of biological sciences, 16(6), 994-1009 (2020-03-07)
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Protokoły
Store the cryovials in a liquid nitrogen storage tank immediately upon arrival.
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