354-05A

Human Aortic Smooth Muscle Cells: HAOSMC, adult

• Synonim(y): Komórki HAOSMC
• Kod UNSPSC: 41106514
• NACRES: NA.81

Właściwości

• pochodzenie biologiczne: human aorta (normal, tunica intima and tunica media, fibrous plaque-free)
• Poziom jakości: 100
• opakowanie: pkg of 500,000 cells
• producent / nazwa handlowa: Cell Applications, Inc
• tryb wzrostu: Adherent
• kariotyp: 2n = 46
• morfologia: smooth muscle
• metody: cell culture | mammalian: suitable
• powiązane choroby: cardiovascular diseases
• Warunki transportu: dry ice
• temp. przechowywania: −196°C

Opis

Opis ogólny

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Human Aortic Smooth Muscle Cells (HAOSMC) provide an excellent model system to study all aspects of cardiovascular function and disease, especially those related to mechanisms of hyperplasia and hypertrophy of intimal smooth muscle cells leading to vascular occlusion in atherosclerosis and stent restenosis.

HAOSMC have been utilized in dozens of research studies, for example, to:elucidate cytokines and growth factors signaling pathways implicated in the molecular regulation of smooth muscle cell proliferation, migration, and overall vascular function (Liu, 2009; Tan, 2009; Seymour, 2010; Chen, 2011; Hirase, 2013; Stein, 2013):

• Understand hyperglycemia-related risk factors for atherosclerosis in diabetes patients (Maier, 2010), as well as effects of ethanol on vascular calcification (Oros, 2012)
• Investigate extracellular elastic matrix deposition and its role in cardiovascular health, repair of damaged vasculature and successful tissue engineering (Gacchina, 2010, 2011; Venkataraman, 2012; Phillippi, 2013)
• Study mechanisms and effects of mechanoregulation on proliferation and function of smooth muscle cells (Jiang, 2009; Venkataraman, 2013, 2014), and develop advanced stent technology, including novel surface materials, and drug and gene delivery systems to prevent restenosis and other occlusive vasculopathies (Brito, 2010; Deshpande, 2013; Kakade, 2013; Lamichhane, 2013)

Characterization: Positive for smooth muscle cell specific alpha-actin expression.

Pochodzenie linii komórkowej

Aorta

Zastosowanie

aortic wall contraction, role of smc under normal conditions, blood pressure, distribution of oxygenated blood through systemic circulation

Uwaga dotycząca przygotowania

• Can be cultured at least 16 doublings

Rutyna subkultury

Please refer to the HAOSMC Culture Protocol.

Oświadczenie o zrzeczeniu się odpowiedzialności

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable