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Key Documents

239M-1

Sigma-Aldrich

Collagen Type IV (CIV22) Mouse Monoclonal Antibody

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About This Item

Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

mouse

Poziom jakości

100
500

białko sprzężone

unconjugated

forma przeciwciała

culture supernatant

rodzaj przeciwciała

primary antibodies

klon

CIV22, monoclonal

opis

For In Vitro Diagnostic Use in Select Regions (See Chart)

Postać

buffered aqueous solution

reaktywność gatunkowa

human

opakowanie

vial of 0.1 mL concentrate (239M-14)
vial of 0.5 mL concentrate (239M-15)
bottle of 1.0 mL predilute (239M-17)
vial of 1.0 mL concentrate (239M-16)
bottle of 7.0 mL predilute (239M-18)

producent / nazwa handlowa

Cell Marque

metody

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

izotyp

IgG1

kontrola

lung

Warunki transportu

wet ice

temp. przechowywania

2-8°C

informacje o genach

human ... COL4A1(1282)

Opis ogólny

Collagen Type IV is the major component of the basal lamina so antibodies to this molecule confirm its presence and reveal the morphological appearance of the structure. Normal tissue stains with this antibody in a fashion consistent with the sites of mesenchymal elements and epithelial basal laminae. Anti-Collagen IV can also be useful in the classification of soft tissue tumors: schwannomas and leiomyomas. Their well-differentiated, malignant counterparts usually immunoreact with this antibody. The vascular nature of neoplasms, hemangiopericytoma, angiosarcoma and epithelioid hemangioendothelioma can be revealed by this antibody with greater reliability than non-specific stains (e.g. silver reticulum)

Jakość


IVD

IVD

IVD

RUO

Powiązanie

Collagen Type IV Positive Control Slides, Product No. 239S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Postać fizyczna

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Uwaga dotycząca przygotowania

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Inne uwagi

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informacje prawne

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

K Schmehl et al.
International journal of colorectal disease, 15(1), 39-48 (2000-04-15)
Imbalances in epithelium-matrix interactions have been discussed as a pathomechanism in ulcerative colitis, causing a colonic mucosal barrier dysfunction. Laminin, the major noncollagenous component of the basement membrane, plays a role in epithelial basal lamina formation and promotes differentiation of
Shaima M Almasry et al.
International journal of immunopathology and pharmacology, 30(3), 282-296 (2017-08-12)
Effects of ribavirin on the structure of peritubular sheath (PS) of seminiferous tubules and on testicular functions were studied. We found that ribavirin at a dose of 4 mg/kg/day for 4 weeks produced a significant reduction in testosterone level (6.3 ± 0.2; P < 0.001) and
Origin and significance of the basal lamina and some interstitial fibrillar components in epithelial neoplasms.
V E Gould et al.
Pathology annual, 11, 353-386 (1976-01-01)
M Määttä et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 49(6), 711-726 (2001-05-25)
Laminins (Ln), together with Type IV collagen and nidogen-1, form the structural integrity of the basement membranes (BM). In this study we used immunohistochemistry to show the distribution of laminin chains alpha1, alpha3, alpha5, beta1, beta2, beta3, gamma1, gamma2, as
A Félix et al.
Human pathology, 30(8), 964-969 (1999-08-19)
Laminin and collagen have been studied in several tumor types and their immunomorphological expression correlated with tumor morphogenesis, local invasiveness, and metastatic behavior. In a series of 53 cases of pleomorphic adenomas (PA) and 16 cases of carcinomas ex-pleomorphic adenoma

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