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Dokumenty

T1700000

Tolbutamide

European Pharmacopoeia (EP) Reference Standard

Synonim(y):

1-Butyl-3-(4-methylphenylsulfonyl)urea, N-[(Butylamino)carbonyl]-4-methylbenzenesulfonamide

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About This Item

Wzór empiryczny (zapis Hilla):
C12H18N2O3S
Numer CAS:
64-77-7
Masa cząsteczkowa:
270.35
Beilstein:
1984428
Numer MDL:
MFCD00027169
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
329826684
NACRES:
NA.24

klasa czystości

pharmaceutical primary standard

rodzina API

tolbutamide

producent / nazwa handlowa

EDQM

Zastosowanie

pharmaceutical (small molecule)

format

neat

temp. przechowywania

2-8°C

ciąg SMILES

CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1

InChI

1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)

Klucz InChI

JLRGJRBPOGGCBT-UHFFFAOYSA-N

informacje o genach

human ... ABCC8(6833) , KCNJ11(3767)

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Opis ogólny

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Zastosowanie

Tolbutamide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Działania biochem./fizjol.

Anti-diabetic agent. Metabolized by CYP2C9 (tolbutamide hydroxylase).

Opakowanie

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Inne uwagi

Sales restrictions may apply.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

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Certyfikaty analizy (CoA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

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Odwiedź Bibliotekę dokumentów

Ning Wang et al.
ACS nano, 9(3), 3159-3168 (2015-03-12)
Cytochromes P450 (CYPs) enzymes are involved in catalyzing the metabolism of various endogenous and exogenous compounds. A rapid analysis of drug metabolism reactions by CYPs is required because they can metabolize 95% of current drugs in drug development and effective
Paulette B Goforth et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(34), 11405-11415 (2014-08-22)
The adipocyte-derived hormone leptin modulates neural systems appropriately for the status of body energy stores. Leptin inhibits lateral hypothalamic area (LHA) orexin (OX; also known as hypocretin)-producing neurons, which control feeding, activity, and energy expenditure, among other parameters. Our previous
Xiwei Zheng et al.
Journal of chromatography. A, 1371, 82-89 (2014-12-03)
Ultrafast affinity extraction and a multi-dimensional affinity system were developed for measuring free drug fractions at therapeutic levels. This approach was used to compare the free fractions and global affinity constants of several sulfonylurea drugs in the presence of normal
Zhiping Lin et al.
Die Pharmazie, 69(7), 537-541 (2014-07-31)
To investigate the influence of scutellarin on the activities of CYP1A2, CYP2C11, CYP2D1, and CYP3A1/2 in rats in vivo. Scutellarin and saline were intravenously administered to male Wistar rats via the caudal vein for 7 days consecutively. On the 8th
Cheng-Lung Hsu et al.
Oncotarget, 5(8), 2187-2197 (2014-04-20)
Although minoxidil has been used for more than two decades to treat androgenetic alopecia (AGA), an androgen-androgen receptor (AR) pathway-dominant disease, its precise mechanism of action remains elusive. We hypothesized that minoxidil may influence the AR or its downstream signaling.
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