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TGFBMAG-64K-01

Millipore

MILLIPLEX® TGFß1 Magnetic Bead Single Plex Kit - Immunology Multiplex Assay

This Immunology Multiplex Assay is used for the simultaneous quantification of the TGF-β1 biomarker in the following species: Mouse/Human/Rat/Pig/Horse/Rabbit/Guinea Pig/Hamster.

Synonim(y):

10549 test immunologiczny na cytokiny, Zestaw Millipore TGF beta, zestaw transformującego czynnika wzrostu beta 1

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About This Item

Kod UNSPSC:
12161503
eCl@ss:
32161000
NACRES:
NA.47

Poziom jakości

200

reaktywność gatunkowa

rat, canine, feline, nonhuman primates, mouse, human, pig

producent / nazwa handlowa

Milliplex®

assay range

accuracy: 100%
sensitivity: 12 pg/mL
standard curve range: 9.8-2,500 pg/mL

metody

multiplexing: suitable

kompatybilność

configured for Single Plex

metoda wykrywania

fluorometric (Luminex xMAP)

Warunki transportu

wet ice

Powiązane kategorie

Opis ogólny

The transforming growth factor beta (TGFβ) system, a superfamily of cytokines as well as signaling pathways, is highly conserved throughout the animal kingdom. TGFβ functions in immune cell development, angiogenesis, wound healing and embryonic development, bone development and plays a critical role in immune response, heart disease, and cancer. In its normal state TGFβ is one of the few classes of proteins able to inhibit cell growth by halting mitosis at the G1 state, inducing cell differentiation or apoptosis. However, during oncogenesis mutations in the TGFβ signaling pathway result in tumor cell resistance to the effects of normally functioning TGFβ, causing proliferation without regulation. Initial research suggests that VE-cadherin may enhance the mutated TGFβ signaling pathway.

The MILLIPLEX® TGFβ1 Single Plex Magnetic Bead Kit is a single plex kit to be used for the quantification of TGFβ in serum, plasma, tissue/cell lysate and culture supernatant
samples.

The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Cytokines/Chemokines

Specyficzność

In addition to human TGFβ1, the assay can detect TGFβ1 in serum of the following; horse, rabbit, mouse, rat, mini pig, canine, hamster, guinea pig, rhesus monkey and cynomolgous monkey. However, the exact amount of cross reactivity has not been determined.

Zastosowanie

  • Analyte: TGFβ1
  • Recommended Species: In addition to human TGFβ1, the assay can detect TGFβ1 in serum of the following: horse, rabbit, mouse, rat, mini pig, canine, hamster, guinea pig, rhesus monkey and cynomolgus monkey. However, the exact amount of cross reactivity has not been determined.
  • Recommended Sample Type: Serum, plasma, cell/tissue culture supernatants and lysates
  • NOTE: This assay requires a sample acidification treatment using the provided reagents and protocol.
  • Recommended Sample Dilution: 25 μL per well of a 1:30 dilution after acidification treatment of serum and plasma samples; cell/tissue culture samples may require dilution prior to acidification treatment (see protocol for details).
  • Assay Run Time: Overnight (16-18 hours) at 2-8°C or alternatively, 2 hours at room temperature (20-25°C).
  • Research Category: Inflammation & Immunology
  • Research Subcategory: Cardiovascular Disease, Chronic Inflammatory Disease, Immune Disorders, Inflammatory Disease, Rheumatoid Arthritis

Opakowanie

Everything you need in a single kit.

Przechowywanie i stabilność

Recommended storage for kit components is 2 - 8°C.

Informacje prawne

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H290,H312,H314,H317,H411

Klasyfikacja zagrożeń

Acute Tox. 4 Dermal - Aquatic Chronic 2 - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1A - Skin Sens. 1

Kod klasy składowania

8A - Combustible corrosive hazardous materials

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Jorge Carrascal et al.
European journal of immunology, 46(3), 593-608 (2015-12-08)
Autoreactive B lymphocytes play a key role as APCs in diaebetogenesis. However, it remains unclear whether B-cell tolerance is compromised in NOD mice. Here, we describe a new B lymphocyte transgenic NOD mouse model, the 116C-NOD mouse, where the transgenes
Low-dose gemcitabine depletes regulatory T cells and improves survival in the orthotopic Panc02 model of pancreatic cancer.
Shevchenko, I; Karakhanova, S; Soltek, S; Link, J; Bayry, J; Werner, J; Umansky, V; Bazhin, AV
International Journal of Cancer. Journal International Du Cancer null
Blockade of A2B adenosine receptor reduces left ventricular dysfunction and ventricular arrhythmias 1 week after myocardial infarction in the rat model.
Zhang, H; Zhong, H; Everett, TH; Wilson, E; Chang, R; Zeng, D; Belardinelli, L; Olgin, JE
Heart Rhythm : the Official Journal of the Heart Rhythm Society null
Xiaonan Li et al.
PloS one, 16(5), e0251293-e0251293 (2021-05-14)
Proteins and lipids of milk fat globule membrane (MFGM) and probiotics are immunomodulatory. We hypothesized that Lactobacillus paracasei ssp. paracasei strain F19 (F19) would augment vaccine antibody and T helper 1 type immune responses whereas MFGM would produce an immune
Vera S Donnenberg et al.
Frontiers in immunology, 13, 846235-846235 (2022-03-01)
Metastasis to the pleural and peritoneal cavities is a common terminal pathway for a wide variety of cancers. This article explores how these unique environments both promote aggressive tumor behavior and suppresses anti-tumor immunity, and ways in which local delivery
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