MABN763
Anti-Ubiquilin 2 Antibody, clone 6H9
clone 6H9, from mouse
Synonim(y):
Ubiquilin-2, Chap1, DSK2 homolog, Protein linking IAP with cytoskeleton 2, PLIC-2, hPLIC-2, Ubiquitin-like product Chap1/Dsk2
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About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
mouse
Poziom jakości
forma przeciwciała
purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
6H9, monoclonal
reaktywność gatunkowa
human, mouse
metody
immunocytochemistry: suitable
western blot: suitable
izotyp
IgG1κ
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... UBQLN2(29978)
Opis ogólny
Ubiquilin-2, also known as Chap1, DSK2 homolog, Protein linking IAP with cytoskeleton 2 (PLIC-2 or hPLIC-2), Ubiquitin-like product Chap1/Dsk2, and encoded by the gene UBQLN2/N4BP4/PLIC2, is a protein that appears to modulate the half-life of proteins destined to be degraded by the proteasome. Ubiquilin 2 binds UBE3A and BTRC ubquitin ligases and interacts with the 19S proteasome subunit to mediate its activity. Ubiquilin 2 is localized to the cytoplasm and nucleus, and colocalizes with proteasome. Ubiquilin 2 is expressed in mitotic cells very strongly; expression is low in non-dividing cells. Defects in Ubiquilin 2 may be associated with ALS form 15 a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis.
Immunogen
Recombinant protein corresponding to human Ubiquilin 2.
Zastosowanie
Detect Ubiquilin-2 using this mouse monoclonal antibody, Anti-Ubiquilin 2 Antibody, clone 6H9 validated for use in western blotting & ICC.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Signaling
Developmental Signaling
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Ubiquilin 2 in 10 µg of SH-SY5Y and NIH-3T3 cell lysate.
Immunocytochemistry Analysis: A representative lot detected Ubiquilin 2 in HeLa cells.
Immunocytochemistry Analysis: A representative lot detected Ubiquilin 2 in HeLa cells.
Jakość
Evaluated by Western Blotting in U-251 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Ubiquilin 2 in 10 µg of U-251 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Ubiquilin 2 in 10 µg of U-251 cell lysate.
Opis wartości docelowych
~66 kDa observed
Postać fizyczna
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing PBS, 50% glycerol, and 0.05% sodium azide.
Przechowywanie i stabilność
Stable for 1 year at -20°C from date of receipt.
Inne uwagi
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Certyfikaty analizy (CoA)
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