MABF41

Anti-Interleukin-6 (IL-6) Antibody, clone 1G3

clone AB42_51.38C8.1G3, from mouse

• Synonim(y): interleukin 6 (interferon, beta 2), IFN-beta-2, B-cell stimulatory factor 2, interleukin-6, Interferon beta-2, B cell stimulatory factor-2, Hybridoma growth factor, B-cell differentiation factor, CTL differentiation factor, interleukin BSF-2
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: mouse
• Poziom jakości: 100
• forma przeciwciała: purified immunoglobulin
• klon: AB42_51.38C8.1G3, monoclonal
• reaktywność gatunkowa: human
• metody: western blot: suitable
• izotyp: IgG2bκ
• numer dostępu NCBI: NP_000591
• numer dostępu UniProt: P05231
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified

Opis

Opis ogólny

Interleukin-6 (IL-6) is a pro-inflammatory cytokine that seems to be involved in the late stages of CTL generation. Other biological functions also include amplification and the inflammatory response. Combination therapies including IL-6 have been shown to have positive effects on specific malignant tumor types. The accumulation of IL-6 in the CNS is usually detrimental and can contribute to pathology of CNS diseases. IL-6 signaling is negatively regulated by TGF-beta, which down regulates STAT1, STAT3 and ICAM-1 expression. IL-6 expression has been linked to inflammatory bowel disease (IBD) and is also the primary clinical target for IBD. Clinical use of an antibody for the IL-6 receptor (IL-6R) has been promising in treating rheumatoid arthritis, systemic juvenile idiopathic arthritis and Castleman’s disease.

Immunogen

Human IL-6 fused to the soluble domain of the IL-6R.

Zastosowanie

Anti-Interleukin-6 (IL-6) Antibody, clone 1G3 is an antibody against Interleukin-6 (IL-6) for use in WB.

Research Category
Inflammation & Immunology

Research Sub Category
Cytokines & Cytokine Receptors

Jakość

Evaluated by Western Blot with human IL-6 recombinant protein.

Western Blot Analysis: 0.5 g/mL of this antibody detected 10 g of human IL-6 recombinant protein.

Opis wartości docelowych

~21 kDa observed

Powiązanie

Replaces: 04-1095

Postać fizyczna

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Komentarz do analizy

Control
Human IL-6 recombinant protein

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable