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MAB5740

Sigma-Aldrich

Anti-Radial Glial Cell Marker-2 Antibody, clone RC2

clone RC2, from mouse

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About This Item

Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

pochodzenie biologiczne

mouse

Poziom jakości

forma przeciwciała

purified antibody

rodzaj przeciwciała

primary antibodies

klon

RC2, monoclonal

reaktywność gatunkowa

mouse

metody

immunohistochemistry: suitable

izotyp

IgMλ

Warunki transportu

wet ice

docelowa modyfikacja potranslacyjna

unmodified

Opis ogólny

The monoclonal antibody Radial Glial Cell Marker-2, clone RC2 (RC2) was generated in mouse by conventional hybridoma methodology. The antigen recognized by RC2 is robust, allowing aldehyde fixation appropriate to high resolution light and electron microscopic analyses. From the neural tube stage of fetal development the antibody delineates throughout the central nervous system a subpopulation of neuroepithelial cells which have a radial bipolar morphology. RC2 also recognizes monopolar cell forms in the spinal cord and the cerebellum as early as E15, and in the dentate gyrus of the hippocampal formation from the day of birth. Monopolar forms in the cerebellum are inferred to be progenitors of Bergmann glia. The robustness of the antigen recognized by RC2 makes this probe a valuable tool to study the morphological transformations of the bipolar radial glia during their mitotic turnover. It also provides a sensitive stain for the study of the organization and the histogenetic role of the overall radial fiber system (3).

Specyficzność

Detects radial glial cell marker-2
Other species have not been tested.

Immunogen

Embryonic rat brain

Zastosowanie

Anti-Radial Glial Cell Marker-2 Antibody, clone RC2 detects level of Radial Glial Cell Marker-2 & has been published & validated for use in IH.
Research Category
Neuroscience
Research Sub Category
Neuronal & Glial Markers

Postać fizyczna

Ammonium sulfate purified mouse monoclonal in PBS with 0.05% NaN3.
Format: Purified

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Expression and immunolocalization of Gpnmb, a glioma-associated glycoprotein, in normal and inflamed central nervous systems of adult rats.
Huang, JJ; Ma, WJ; Yokoyama, S
Brain and Behavior null
Lei Wang et al.
Nature neuroscience, 19(7), 888-896 (2016-05-24)
The unique mental abilities of humans are rooted in the immensely expanded and folded neocortex, which reflects the expansion of neural progenitors, especially basal progenitors including basal radial glia (bRGs) and intermediate progenitor cells (IPCs). We found that constitutively active
Tania Aguado et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(5), 1551-1561 (2006-02-03)
Endocannabinoids exert an important neuromodulatory role via presynaptic cannabinoid CB1 receptors and may also participate in the control of neural cell death and survival. The function of the endocannabinoid system has been extensively studied in differentiated neurons, but its potential
Suyan Li et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(37), 14809-14815 (2013-09-13)
Current models of brain development support the view that VEGF, a signaling protein secreted by neuronal cells, regulates angiogenesis and neuronal development. Here we demonstrate an autonomous and pivotal role for endothelial cell-derived VEGF that has far-reaching consequences for mouse

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