MAB5352
Anti-Notch 1 Antibody, clone mN1A
clone mN1A, Chemicon®, from mouse
Synonim(y):
Anty-AOS5, Anty-AOVD1, Anty-HN1, Anty-TAN1
Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
mouse
Poziom jakości
forma przeciwciała
purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
mN1A, monoclonal
reaktywność gatunkowa
rat, mouse, feline
opakowanie
antibody small pack of 25 μg
producent / nazwa handlowa
Chemicon®
metody
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
izotyp
IgG1
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
ambient
temp. przechowywania
2-8°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... NOTCH1(4851)
Opis ogólny
Notch1 consists of three domains. The extracellular domain containing 36 epidermal growth factor (EGF) repeats and 3 lin-12/Notch repeats (LNR) and functions as a receptor in cell-cell interactions. There is a single transmembrane domain (TM). The intracellular domain contains six cdc10/ankyrin repeats (cdc10) and the newly defined Notch cytokine response (NCR) region, which contains a putative bipartite NLS (nuclear localization signal).
Specyficzność
Recognizes Notch1, intracellular domain. The antibody has a high affinity for the "activated" intracellular form of Notch1, but a low affinity for the full-length (unprocessed or heterodimeric cell surface) forms. No reactivity with Notch2, 3 or 4.
Immunogen
Cdc10-NCR region of mouse Notch1 expressed as a GST fusion protein.
Zastosowanie
Anti-Notch 1 Antibody, clone mN1A is a high quality Mouse Monoclonal Antibody for the detection of Notch 1 & has been validated in ICC, IHC, IP & WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Western blot using ECL
Immunohistochemistry
Immunocytochemistry
Immunoprecipitation
Optimal working dilutions must be determined by the end user.
Immunohistochemistry
Immunocytochemistry
Immunoprecipitation
Optimal working dilutions must be determined by the end user.
Opis wartości docelowych
272.5 kDa (also 230 kDa processed form)
Powiązanie
Replaces: 04-1046
Postać fizyczna
Format: Purified
Protein A purified
Purified immunoglobulin. Liquid.
Przechowywanie i stabilność
Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Komentarz do analizy
Control
In fetal tissues, use spleen, brain stem and lung. In most adult tissues, use lymphoid tissues.
In fetal tissues, use spleen, brain stem and lung. In most adult tissues, use lymphoid tissues.
Inne uwagi
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informacje prawne
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
MDM2 protein-mediated ubiquitination of numb protein: identification of a second physiological substrate of MDM2 that employs a dual-site docking mechanism.
Sczaniecka, M; Gladstone, K; Pettersson, S; McLaren, L; Huart, AS; Wallace, M
The Journal of Biological Chemistry null
Huan-You Wang et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 23(6), 773-780 (2010-03-30)
Primary effusion lymphoma is a human herpes virus 8 (HHV-8)-associated large cell lymphoma of body cavities. Detailed large-scale clinicopathological studies are rarely reported, and the underlying mechanism of lymphomagenesis remains elusive. In the present report, we studied the clinicodemographic, immunophenotypic
Shu Li et al.
Molecular medicine reports, 9(6), 2233-2238 (2014-03-20)
Brain arteriovenous malformation (bAVM) is currently one of the most common cerebral vascular diseases, which result in severe clinical outcomes. The Notch signaling pathway is involved in vasculogenesis and angiogenesis, as well as vascular remodeling and arteriovenous differentiation in multiple
David F Fischer et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 19(11), 1451-1458 (2005-08-30)
Down syndrome (DS) patients suffer from mental retardation, but also display enhanced beta-APP production and develop cortical amyloid plaques at an early age. As beta-APP and Notch are both processed by gamma-secretase, we analyzed expression of the Notch signaling pathway
Xue-Liang Zhou et al.
Journal of cellular physiology, 234(6), 8834-8845 (2018-10-15)
During myocardial infarction (MI), cardiac fibroblasts (CFs) transform into myofibroblast (CMT). This study aimed to investigate the crosstalk of Notch1 and transforming growth factor-β1 (TGF-β1)/Smad3 signaling in the regulation of CMT and myocardial fibrosis. Primary CFs were isolated from young
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