MAB4145
Anti-BCRP Antibody, clone BXP-34
culture supernatant, clone BXP-34, Chemicon®
Synonim(y):
Breast Cancer Resistance Protein, Placenta-specific ATP Binding Cassette Transporter, ATP-binding Cassette, Sub Family G, member 2 (ABCG2)
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About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.43
Polecane produkty
pochodzenie biologiczne
mouse
Poziom jakości
forma przeciwciała
culture supernatant
rodzaj przeciwciała
primary antibodies
klon
BXP-34, monoclonal
reaktywność gatunkowa
human
producent / nazwa handlowa
Chemicon®
metody
immunocytochemistry: suitable
immunohistochemistry: suitable
moc wejściowa
sample type hematopoietic stem cell(s)
sample type neural stem cell(s)
izotyp
IgG1
przydatność
not suitable for Western blot
not suitable for immunohistochemistry (Paraffin)
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... ABCG2(9429)
Opis ogólny
The 72 kDa breast cancer resistance protein (BCRP) is the second member of the subfamily G of the human ATP binding cassette (ABC) transporter superfamily and thus also designated as ABCG2. BCRP is a half-transporter consisting of only 1 nucleotide binding domain followed by 1 membrane-spanning domain. Current experimental evidence suggests that BCRP may function as a homodimer or homotetramer. Overexpression of BCRP is associated with high levels of resistance to a variety of anticancer agents. BCRP expression has been detected in a large number of hematological malignancies and solid tumors, indicating that this transporter may play an important role in clinical drug resistance of cancers. In addition to its role to confer resistance against chemotherapeutic agents, BCRP actively transports structurally diverse organic molecules, conjugated or unconjugated, such as estrone-3-sulfate, 17-β-estradiol 17-(β-D-glucuronide), and methotrexate. BCRP is highly expressed in the placental syncytiotrophoblasts, in the apical membrane of the epithelium in the small intestine, in the liver canalicular membrane, and at the luminal surface of the endothelial cells of human brain microvessels. This strategic and substantial tissue localization indicates that BCRP also plays an important role in absorption, distribution, and elimination of drugs that are BCRP substrates.
Specyficzność
This antibody reacts with an internal epitope of the Breast Cancer Resistance Protein (BCRP), a 70 kDa transmembrane half-transporter which is involved in multidrug resistance. The antibody does not cross-react with human MDR1, MRP1, MRP2 or MRP5 gene products.
Immunogen
The Mitoxanthrone resistant, BCRP-overexpressing cell line MCF7-MR.
Zastosowanie
Detect BCRP using this Anti-BCRP Antibody, clone BXP-34 validated for use in IC, IH.
Immunocytochemistry: 1:20 - 1:50 on acetone fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections
Not suitable for paraffin-embedded tissues or for Western blotting
Optimal working dilutions must be determined by end user.
Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections
Not suitable for paraffin-embedded tissues or for Western blotting
Optimal working dilutions must be determined by end user.
Research Category
Stem Cell Research
Stem Cell Research
Research Sub Category
Hematopoietic Stem Cells
Hematopoietic Stem Cells
Opis wartości docelowych
70 kDa
Postać fizyczna
Liquid containing 0.7% BSA and 0.1% sodium azide.
Przechowywanie i stabilność
Maintain refrigerated at 2-8°C for up to 6 months. For long-term storage store at -20°C.
Komentarz do analizy
Control
MCF-7 cells
MCF-7 cells
Inne uwagi
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informacje prawne
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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polecane
Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Certyfikaty analizy (CoA)
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Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Wen Jing et al.
Oncology letters, 20(6), 309-309 (2020-10-24)
Most patients with advanced leukemia eventually die from multidrug resistance (MDR). Chemotherapy-resistant leukemia cells may lead to treatment failure and disease relapse. Overexpression of ATP-binding cassette subfamily G member 2 (ABCG2) leads to MDR, which serves as a potential biomarker
Maria Paprocka et al.
European journal of haematology, 99(5), 415-422 (2017-08-15)
It is well established that expression of multi-drug resistance (MDR) proteins (MDR1, BCRP, MDR3, MRP1, and LRP) in leukemic blasts correlates with acute myeloid leukemia (AML) patients' clinical response. Assuming that leukemic stem cells (LSC) are resistant to chemotherapy and
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