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MAB2074Z

Sigma-Aldrich

Anti-Integrin αVβ6 Antibody, clone E7P6, azide free

clone E7P6, Chemicon®, from mouse

Synonim(y):

MAB2074

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About This Item

Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

pochodzenie biologiczne

mouse

Poziom jakości

100

forma przeciwciała

purified immunoglobulin

rodzaj przeciwciała

primary antibodies

klon

E7P6, monoclonal

reaktywność gatunkowa

human

producent / nazwa handlowa

Chemicon®

metody

flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable

izotyp

IgG1

przydatność

not suitable for activity/function inhibition
not suitable for immunohistochemistry (Paraffin)

numer dostępu NCBI

NM_002210.2

numer dostępu UniProt

P06756

Warunki transportu

wet ice

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... ITGAV(3685)

Powiązane kategorie

Specyficzność

Monoclonal antibody MAB2074Z, raised by immunizing Balb/c mice with recombinant secreted human avb6, is useful for flow cytometry and is especially useful for immunocytochemistry. The antibody works well for immunohistochemistry of human tissue, especially under circumstances where upregulation of the receptor is being evaluated. The antibody does not stain formalin-fixed or paraffin-embedded tissues, and may not detect the low-level basal expression of alphavbeta6 in epithelia of healthy adults. This antibody does not recognize the alphaV subunit and does not react with alphaV integrins other than alphavbeta6. Because the antibody is not effective in western blot, it is unknown whether the epitope recognized by the antibody localizes to the alphavbeta6 heterodimer or to the beta6 subunit only.

Immunogen

Recombinant secreted human alphavbeta6.

Zastosowanie

Immunohistochemistry (acetone fixation): Effective for human tissue, especially in circumstances where up-regulation of the receptor is being evaluated. The antibody does not stain formalin-fixed or paraffin-embedded tissues, and may not detect the low-level basal expression of alpavbeta6 in epithelia of healthy adults.

Immunocytochemistry: Effective for F6, HT-29, H441 cell lines (others not tested).

Flow cytometry: Effective for detection of human and monkey alphaVbeta6

Not effective for immunoprecipitation or western blot.

Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Research Sub Category
Integrins
This Anti-Integrin αVβ6 Antibody, clone E7P6, azide free is validated for use in FC, IC, IH for the detection of Integrin αVβ6.

Postać fizyczna

Format: Purified
Sterile-filtered liquid at 1 mg/mL in PBS, containing no preservatives.

Przechowywanie i stabilność

Maintain at 2-8°C in undiluted aliquots for up to 12 months.

Informacje prawne

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Christopher J Legge et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 48(9), 803-809 (2019-07-17)
Patients with oral squamous cell carcinoma currently experience a five-year survival rate of approximately 60% with conventional surgical, chemotherapy and radiotherapy treatments. Magnetic hyperthermia offers an alternative treatment method by utilising the heating properties of magnetic nanoparticles to produce thermal
Epithelial to mesenchymal transition in gingival overgrowth.
Sume SS, Kantarci A, Lee A, Hasturk H, Trackman PC
The American Journal of Pathology null
Interaction of alphaVbeta3 and alphaVbeta6 integrins with human parechovirus 1.
Seitsonen, J; Susi, P; Heikkila, O; Sinkovits, RS; Laurinmaki, P; Hyypia, T; Butcher, SJ
Journal of virology null
Maria L Nystrom et al.
Cancer research, 66(22), 10833-10842 (2006-11-17)
Worldwide oral squamous cell carcinoma (OSCC) represents about 5.5% of all malignancies, with approximately 30,000 new cases each year in the United States. The integrin alpha(v)beta(6) and the enzyme cyclooxygenase-2 (COX-2) are implicated in OSCC progression and have been suggested
Yingshe Zhao et al.
Cancer research, 67(12), 5821-5830 (2007-06-19)
In breast cancer bone metastasis, tumor cells stimulate osteoclast-mediated bone resorption, and bone-derived growth factors released from resorbed bone stimulate tumor growth. The alphavbeta3 integrin is an adhesion receptor expressed by breast cancer cells and osteoclasts. It is implicated in
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