ABS535
Anti-Arginase-1 Antibody
from chicken
Synonim(y):
Type 1 Arginase
ARG1
Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
chicken
Poziom jakości
forma przeciwciała
purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
polyclonal
reaktywność gatunkowa
guinea pig, human, mouse, rat
metody
immunohistochemistry: suitable
western blot: suitable
izotyp
IgY
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... ARG1(383)
mouse ... Arg1(11846)
rat ... Arg1(29221)
Opis ogólny
Arginase-1, the protein encoded by the ARG1 gene, is the enzyme that catalyzes the breakdown of L-arginine into ornithine and urea. ARG1 is a key player in the Urea cycle. There are two distinct isoforms of Arginase, Arginase I and Arginase II. Arginase I (also called the liver type arginase or Type 1 arginase) is a highly expressed cytosolic enzyme in the liver and other tissues, including the brain. Arginase II or kidney-type arginase is also widely expressed at low levels in many tissues but localized to the mitochondria primarily. Interestingly, Arginase 1 has neuroprotective properties. Arginase I is essential for protecting motor neurons from nitric oxide dependent apoptosis that can be induced upon cellular stress or trophic factor removal. By suppressing nitric oxide production, Arginase prevents the formation of peroxynitrite and its subsequent cellular toxicity. Furthermore, Arginase 1 appears to play critical roles throughout the CNS for survival and regeneration of neurons and axons. In cancer, Arginase 1, already a useful marker for hepatocytes is also an excellent marker for hepatocellular cancers.
Immunogen
Full-length recombinant protein corresponding to Rat Arginase-1.
Zastosowanie
Immunohistochemistry Analysis: A representative lot detected Arginase-1 in bronchoalveolar lavage cells (Zimmermann, N., et al. (2003). J. Clin. Invest. 111:1863–1874 (2003)).
Western Blotting Analysis: A representative lot detected Arginase-1 in RAW cell lysate (Morris, S., et al. (1998). Am J Physiol Endocrinol Metab 275:E740-E747, 1998).
Western Blotting Analysis: A representative lot detected Arginase-1 in RAW cell lysate (Morris, S., et al. (1998). Am J Physiol Endocrinol Metab 275:E740-E747, 1998).
Research Category
Signaling
Signaling
This Anti-Arginase-1 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of Arginase-1.
Jakość
Evaluated by Western Blotting in mouse LN tissue lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected Arginase-1 in 10 µg of mouse LN tissue lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected Arginase-1 in 10 µg of mouse LN tissue lysate.
Opis wartości docelowych
~ 38 kDa observed
Postać fizyczna
Format: Purified
IgY purified from Yolk
Purified chicken Polyclonal other in buffer containing PBS with 0.05% sodium azide.
Przechowywanie i stabilność
Stable for 1 year at 2-8°C from date of receipt.
Inne uwagi
Concentration: Please refer to lot specific datasheet.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Ta strona może zawierać tekst przetłumaczony maszynowo.
Nie możesz znaleźć właściwego produktu?
Wypróbuj nasz Narzędzie selektora produktów.
Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Tim Tian Y Han et al.
Frontiers in bioengineering and biotechnology, 9, 642465-642465 (2021-04-06)
Cell-based therapies involving the delivery of adipose-derived stromal cells (ASCs) on decellularized adipose tissue (DAT) scaffolds are a promising approach for soft tissue augmentation and reconstruction. Our lab has recently shown that culturing human ASCs on DAT scaffolds within a
Nicolas De Vos et al.
Clinics and research in hepatology and gastroenterology, 45(3), 101478-101478 (2020-07-06)
Preoperative imaging and histopathology, immunohistochemistry and molecular analysis after resection of 2 hepatocellular adenomas (HCAs) (20 and 2cm) in a 53-year-old female patient were performed. On imaging, the large lesion resembled a myxoid HCA, while the small lesion resembled a
Asiyeh Golabchi et al.
Biomaterials, 180, 225-239 (2018-07-28)
The chronic performance of implantable neural electrodes is hindered by inflammatory brain tissue responses, including microglia activation, glial scarring, and neuronal loss. Melatonin (MT) has shown remarkable neuroprotective and neurorestorative effects in treating central nervous system (CNS) injuries and degeneration
Julia S Brunner et al.
Nature communications, 11(1), 431-431 (2020-01-24)
Multinucleated giant cells (MGCs) are implicated in many diseases including schistosomiasis, sarcoidosis and arthritis. MGC generation is energy intensive to enforce membrane fusion and cytoplasmic expansion. Using receptor activator of nuclear factor kappa-Β ligand (RANKL) induced osteoclastogenesis to model MGC
Matthew J Kan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(15), 5969-5982 (2015-04-17)
The pathogenesis of Alzheimer's disease (AD) is a critical unsolved question; and although recent studies have demonstrated a strong association between altered brain immune responses and disease progression, the mechanistic cause of neuronal dysfunction and death is unknown. We have
Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.
Skontaktuj się z zespołem ds. pomocy technicznej