ABS192

Anti-phospho-SRPK2 (Ser497) Antibody

from rabbit, purified by affinity chromatography

• Synonim(y): SRSF protein kinase 2, SFRS protein kinase 2, Serine/arginine-rich protein-specific kinase 2, SR-protein-specific kinase 2, SRSF protein kinase 2 N-terminal, SRSF protein kinase 2 C-terminal
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• klon: polyclonal
• application: WB
• reaktywność gatunkowa: hamster, mouse, human
• metody: western blot: suitable
• citations: 1

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• oczyszczone przez: affinity chromatography
• reaktywność gatunkowa: hamster, mouse, human
• reaktywność gatunkowa (przewidywana na podstawie homologii): rat (based on 100% sequence homology), Xenopus (based on 100% sequence homology)
• metody: western blot: suitable
• numer dostępu NCBI: NP_872633
• numer dostępu UniProt: P78362
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: phosphorylation (pSer497)
• informacje o genach: human ... SRPK2(6733)

Opis

Opis ogólny

SRPK2 is also known as SRSF protein kinase 2, SFRS protein kinase 2, and Serine/arginine-rich protein-specific kinase 2. SRPK2 is a kinase which is involved in the phosphorylation of SR splicing factors, and the regulation of splicing. SRPK2 also promotes neuronal apoptosis, plays an essential role in splicesomal B complex formation, and mediates hepatitis B virus (HBV) replication and core protein phosphorylation. SRPK2 is highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney.

Specyficzność

This antibody recognizes the protein kinase domain of SRPK2 phosphorylated at Ser497.

Immunogen

Epitope: Protein kinase domain

KLH-conjugated linear peptide corresponding to the protein kinase domain of human SRPK2 (Ser497).

Zastosowanie

Anti-phospho-SRPK2 (Ser497) Antibody is a highly specific rabbit polyclonal antibody, that targets SRPK & has been tested in western blotting.

Research Category
Signaling

Research Sub Category
Developmental Signaling

Jakość

Evaluated by Western Blotting in NIH3T3 cell lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected SRPK2 (Ser497) in 10 µg of NIH3T3 cell lysate and Insulin treated NIH3T3 cell lysate.

Opis wartości docelowych

~120 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~77 kDa and ~79 kDa Uniprot states 8 phosphorylation sites are known to exist.

Postać fizyczna

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Komentarz do analizy

Control
NIH3T3 cell lysate and Insulin treated NIH3T3 cell lysate

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable