ABN439

Anti-PQBP1 Antibody

from rabbit, purified by affinity chromatography

• Synonim(y): Polyglutamine-binding protein 1, PQBP-1, PQBP 1, 38 kDa nuclear protein containing a WW domain, Npw38, Polyglutamine tract-binding protein 1
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• forma przeciwciała: affinity isolated antibody
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• oczyszczone przez: affinity chromatography
• reaktywność gatunkowa: human
• reaktywność gatunkowa (przewidywana na podstawie homologii): primate (based on 100% sequence homology)
• metody: immunohistochemistry: suitable; western blot: suitable
• numer dostępu NCBI: NP_001027553
• numer dostępu UniProt: O60828
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... PQBP1(10084)

Opis

Opis ogólny

Polyglutamine-binding protein 1 (PQBP1), also known as PQBP-1, 38 kDa nuclear protein containing a WW domain, Npw38, Polyglutamine tract-binding protein 1, is encoded by the gene name PQBP1/ NPW38/ JM26. Recent studies have implied that PQBP1 may suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. PQBP1 has also been shown to activate transcription directly, or via association with the transcription machinery. PQBP1 might be involved in ATXN1 mutant-induced cell death. PQBP1 has been shown to interact with POU3F2/Brn-2, ATXN1, TXNL4A, HTT and AR. Interaction with ATXN1 correlates positively with the length of the polyglutamine tract. In addition, PQBP1 interacts with RNA polymerase II large subunit in a phosphorylation-dependent manner. PQBP1 forms a ternary complex with ATXN1 mutant and phosphorylated RNA polymerase II. PQBP1 is widely expressed with high levels in heart, skeletal muscle, pancreas, spleen, thymus, prostate, ovary, small intestine and peripheral blood leukocytes. Mutations in PQBP1 have been associated with Renpenning syndrome 1 (RENS1), an X-linked mental retardation syndrome characterized by mental retardation, microcephaly, short stature, and small testes.

Immunogen

Epitope: unknown

KLH-conjugated linear peptide corresponding to the unknown of Human PQBP1.

Zastosowanie

Anti-PQBP1 is an antibody against PQBP1 for use in WB, IH.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected PQBP1 in human cardiac myocytes and pancreatic tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

Jakość

Evaluated by Western Blotting in Human Hippocampus tissue lysate.

Western Blotting Analysis: A 0.5 µg/mL dilution of this antibody detected PQBP1 in 10 µg of Human Hippocampus tissue lysate.

Opis wartości docelowych

~38 kDa observed. Predicted to cross-react to Isoforms 1, 2, 3, and 6. Maybe detected upon longer exposure times.

Postać fizyczna

Antigen Affinity Purified

Purified rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Inne uwagi

Concentration: Please refer to lot specific datasheet.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable