AB2256
Anti-GABA B Receptor R1 Antibody
serum, from guinea pig
Synonim(y):
GABA-B receptor, GABA-B receptor 1, GABAB, subunit 1c, gamma-aminobutyric acid (GABA) B receptor 1, gamma-aminobutyric acid B receptor 1, seven transmembrane helix receptor
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About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
guinea pig
Poziom jakości
forma przeciwciała
serum
rodzaj przeciwciała
primary antibodies
klon
polyclonal
reaktywność gatunkowa
mouse, human, rat
metody
immunohistochemistry: suitable
western blot: suitable
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
wet ice
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
mouse ... Gabbr1(54393)
Opis ogólny
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.
Specyficzność
Cat. # AB2256 recognizes GABA B Receptor R1 (GABA B R1)
Reactivity with other species has not been determined.
Immunogen
Epitope: C-Terminus
interaction w/ ATF4
interaction w/ ATF4
Recombinant peptide (aa 972-991: PSEPPDRLSCDGSRVHLLYK)
Zastosowanie
Detect GABA B Receptor R1 using this Anti-GABA B Receptor R1 Antibody validated for use in WB, IH.
Immunohistochemistry: Working dilution of 1:3,000 in free floating mouse brain tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Neurotransmitters & Receptors
Jakość
Western Blotting: 1:1,000 dilution from a previous lot detected GABA B R1 on 10µg of rat brain lysate.
Opis wartości docelowych
~100-105 kDa
Postać fizyczna
GST-Depleted Sera with 0.05% NaN3.
Przechowywanie i stabilność
Stable for 1 year at -20ºC from date of receipt.
Komentarz do analizy
Control
Rat brain lysates
Rat brain lysates
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen.
Lancaster, E; Lai, M; Peng, X; Hughes, E; Constantinescu, R; Raizer, J; Friedman et al.
Lancet Neurology null
Aline M Davis et al.
The Journal of comparative neurology, 449(3), 270-280 (2002-07-13)
Gamma-aminobutyric acid (GABA) is a highly abundant neurotransmitter in the brain and the ligand for GABA(A), GABA(B), and GABA(C) receptors. Unlike GABA(A) and GABA(C) receptors, which are chloride channels, GABA(B) receptors are G-protein linked and alter cell-signaling pathways. Electrophysiological studies
Ji-Yong Kang et al.
The Journal of biological chemistry, 292(16), 6621-6632 (2017-02-19)
The behavioral and anatomical deficits seen in fragile X syndrome (FXS) are widely believed to result from imbalances in the relative strengths of excitatory and inhibitory neurotransmission. Although modified neuronal excitability is thought to be of significance, the contribution that
Matthew T Valley et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(37), 14660-14665 (2013-09-13)
Neuronal regeneration occurs naturally in a few restricted mammalian brain regions, but its functional significance remains debated. Here we search for unique features in the synaptic outputs made by adult-born granule cell interneurons in the mouse olfactory bulb using optogenetic
Gennady Dvoryanchikov et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(15), 5782-5791 (2011-04-15)
Taste buds consist of at least three principal cell types that have different functions in processing gustatory signals: glial-like (type I) cells, receptor (type II) cells, and presynaptic (type III) cells. Using a combination of Ca2+ imaging, single-cell reverse transcriptase-PCR
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