8.17058

Maleic acid

EMPROVE^® ESSENTIAL, Ph. Eur., NF

• Synonim(y): cis-Butenedioic acid, Toxilic acid
• Wzór liniowy: HO₂CCH=CHCO₂H
• Numer CAS: 110-16-7
• Masa cząsteczkowa: 116.07
• Beilstein: 605762
• Numer MDL: MFCD00063177
• Kod UNSPSC: 12352106
• Numer indeksu EC: 203-742-5

Właściwości

• agency: NF; Ph. Eur.
• Poziom jakości: 500
• ciśnienie pary: <0.1 hPa ( 20 °C)
• linia produktu: EMPROVE^® ESSENTIAL
• Próba: 99.0-101.0% substance (anhydrous) basis
• Postać: solid
• siła działania: 708 mg/kg LD₅₀, oral (Rat); 1560 mg/kg LD₅₀, skin (Rabbit)
• metody: API processing | cocrystal formation: suitable; API processing | salt formation: suitable
• pH: 1.3 (20 °C, 100 g/L in H₂O)
• mp: 130-135 °C (lit.)
• rozpuszczalność: 478.8 g/L
• gęstość: 1.59 g/mL at 25 °C (lit.)
• ślady kationów: Fe: ≤5 ppm; V: ≤1 ppm; heavy metals (as Pb): ≤10 ppm
• Zastosowanie: liquid formulation; pharmaceutical; semi-solid formulation; solid formulation
• temp. przechowywania: 15-25°C
• ciąg SMILES: OC(=O)\C=C/C(O)=O
• InChI: 1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1-
• Klucz InChI: VZCYOOQTPOCHFL-UPHRSURJSA-N

Opis

Opis ogólny

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Zastosowanie

Maleic acid is typically used as pH adjuster or buffer agent in pharmaceutical formulations. Maleic acid Emprove^® Essential is mainly used in highly regulated pharmaceutical applications.

Informacje prawne

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS05,GHS07
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H302 + H312,H314,H317,H335
• Zwroty wskazujące środki ostrożności: P260 - P271 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1 - Skin Sens. 1 - STOT SE 3
• Organy docelowe: Respiratory system
• Kod klasy składowania: 8A - Combustible corrosive hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 1