613810

TNAP Inhibitor

The TNAP Inhibitor, also referenced under CAS 496014-13-2, controls the biological activity of TNAP. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Synonim(y): 2,5-dimetoksy-N-(chinolin-3-ylo)benzenosulfonamid, niespecyficzny tkankowy inhibitor fosfatazy alkalicznej, MLS-0038949
• Wzór empiryczny (zapis Hilla): C₁₇H₁₆N₂O₄S
• Numer CAS: 496014-13-2
• Masa cząsteczkowa: 344.38
• Numer MDL: MFCD03132123
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥95% (HPLC)
• Formularz: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• kolor: white
• rozpuszczalność: DMSO: 50 mg/mL
• Warunki transportu: ambient
• temp. przechowywania: 2-8°C
• ciąg SMILES: [S](=O)(=O)(Nc2cnc3c(c2)cccc3)c1c(ccc(c1)OC)OC
• InChI: 1S/C17H16N2O4S/c1-22-14-7-8-16(23-2)17(10-14)24(20,21)19-13-9-12-5-3-4-6-15(12)18-11-13/h3-11,19H,1-2H3
• Klucz InChI: JZSPHTPWUXNQGB-UHFFFAOYSA-N

Opis

Opis ogólny

A cell-permeable quinolinyl-benzenesulfonamide compound that acts as a potent reversible inhibitor against tissue-nonspecific (TN) alkaline phosphatase (AP) activity (IC₅₀ = 190 nM) with CYP2C19 being the only other known target, while exhibiting little or no inhibitory activity in over 250 assays involving other enzymes, including, but not limited to, placental and intestinal APs (IC₅₀ >100 µM), PHOSPHO1 phosphatase, and NPP1 phosphodiesterase. Kinetic studies indicate that the inhibition is uncompetitive with respect to the phosphate donor substrate and noncompetitive with respect to the acceptor substrate, indicating an allosteric inhibition mechanism. Subcutaneous dosing in rats in vivo is reported to result in plasma inhibitor concentrations in the therapeutic range (C_max = 1.5 µg/ml 1 hr after 4.13 mg/kg by s.c.).

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Standard Handling (A)

Rekonstytucja

Following reconstitution, aliquot and store at (4°C). Stock solutions are stable for up to 6 months at 4°C.

Inne uwagi

Dahl, R., et al. 2009. J. Med. Chem.52, 6919.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3