539165

Proteasome Inhibitor Set II

The Proteasome Inhibitor Set II controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Postać: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• Warunki transportu: ambient
• temp. przechowywania: −20°C

Opis

Opis ogólny

Contains 5 mg of ALLN (Cat. No. 208719), 100 μg each of Epoxomicin (Cat. No. 324800), and clasto-Lactacystin β-Lactone (Cat. No. 426102). Supplied with a data sheet.

Proteasomes are large multi-subunit protease complexes, which selectively degrade intracellular proteins. A protein marked for degradation is attached to multiple molecules of ubiquitin, a 76-amino acid protein, which escorts it for rapid hydrolysis, by the 26S proteasome. The proteolytic core of this complex consists of the 20S proteasome, which contains multiple peptidase activities and has a molecular mass of ~700 kDa. Recently several potent, cell-permeable proteasome inhibitors have been developed.



The Calbiochem brand offers a set that includes 3 proteasome inhibitors with varying inhibtory effects.



The table below outlines some of the physical and biological properties of these compounds.

Działania biochem./fizjol.

Primary Target
calpain 1, calpain 2

Secondary Target
cathepsin B, cathepsin L

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Standard Handling (A)

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids