5.00111

Cocarboxylase tetrahydrate

(thiamine pyrophosphate tetrahydrate), EMPROVE^® API

• Synonim(y): Cocarboxylase tetrahydrate
• Wzór empiryczny (zapis Hilla): C₁₂H₁₈N₄O₇P₂S · 4H₂O
• Numer CAS: 68684-55-9
• Masa cząsteczkowa: 496.37
• Numer MDL: MFCD00150680
• Kod UNSPSC: 12352107
• Numer indeksu EC: 205-230-7

Właściwości

• Poziom jakości: 600
• linia produktu: EMPROVE^® API
• Formularz: solid
• pH: 2.4-3.2 (20 °C, 100 g/L in H₂O)
• rozpuszczalność: 55 g/L
• gęstość nasypowa: 450 kg/m³
• Zastosowanie: liquid formulation; pharmaceutical; semi-solid formulation; solid formulation
• temp. przechowywania: 2-25°C
• ciąg SMILES: [P](=O)([O-])(O[P](=O)([O-])O)OCCc1[s]c[n+](c1C)Cc2c(nc(nc2)C)N.O.O.O.O.[H+]
• InChI: 1S/C12H18N4O7P2S.4H2O/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13;;;;/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21);4*1H2
• Klucz InChI: KLOLNRGPRQYTIW-UHFFFAOYSA-N

Opis

Opis ogólny

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Zastosowanie

Cocarboxylase tetrahydrate Emprove^® API is a source for Vitamin B1 for use in clinical nutrition, vitamin supplements and infusion for Vitamin B1 deficiency. Cocarboxylase Tetrahydrate (thiamine diphosphoric acid ester tetrahydrate) Emprove^® API is manufactured according to ICH Q7 guidelines. An ASMF is available.

Informacje prawne

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Oświadczenie o zrzeczeniu się odpowiedzialności

The substance 5.00111 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable