345744

Ganglioside GT_1b, Trisialo, Triammonium Salt, Bovine Brain

Inhibits Con A-stimulated mitogenesis in murine T cells.

• Synonim(y): Ganglioside GT_1b, Trisialo, Triammonium Salt, Bovine Brain, Neu5Acα2,3Galβ1,3GalNAcβ1,4(Neu5Acα2,8Neu5Acα2,3)Galβ1,4Glcβ1,1 Ceramide, 3NH₄
• Wzór empiryczny (zapis Hilla): C₉₅H₁₆₂N₅O₄₇ · 3NH₄
• Masa cząsteczkowa: 2180.42
• Kod UNSPSC: 12352211
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥98% (TLC)
• Postać: lyophilized
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze
• rozpuszczalność: ethanol: soluble; methanol: soluble
• Warunki transportu: ambient
• temp. przechowywania: −20°C

Opis

Opis ogólny

Inhibits Con A-stimulated mitogenesis in murine T cells. Lymphocyte marker in cancer patients. Readily converted to GD_1b-disialoganglioside by bacterial and other mammalian neuraminidases without detergent or bile salts.

M.W. 2180.5 (based on stearoyl - 18:0).

Trisialoganglioside prepared from bovine gray matter. Readily converted to GD_1b-disialoganglioside by bacterial and mammalian sialidases without detergent or bile salts. Inhibits mitogenesis in concanavalin A-stimulated murine T-cells. Lymphocyte marker in cancer patients.



Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.

Działania biochem./fizjol.

Cell permeable: no

Primary Target
Inhibits Con A-stimulated mitogenesis in murine T cells

Product does not compete with ATP.

Reversible: no

Ostrzeżenie

Toxicity: Irritant (B)

Uwaga dotycząca przygotowania

For use in aqueous systems, dissolve in a small amount of ethanol and then sonicate in buffer or medium, or dissolve the dried sample directly in aqueous buffers by sonication. Solutions can be filter sterilized.

Rekonstytucja

Following reconstitution, store in the refrigerator(4°C). Stock solutions are stable for up to 6 months at 4°C.

Inne uwagi

Hakomori, S. 1985. Cancer Res.45, 2405.
Momoi, T., et al. 1976. Biochim. Biophys. Acta441, 488.
Warren, L. 1959. J. Biol. Chem.234, 1971.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable