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Kluczowe dokumenty

324410

Sigma-Aldrich

Dynasore

≥98% (HPLC), solid, dynamin inhibitor, Calbiochem®

Synonim(y):

Kwas 3-hydroksynaftaleno-2-karboksylowy-(3,4-dihydroksybenzylideno)-hydrazyd, Sore to Dynamin

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About This Item

Wzór empiryczny (zapis Hilla):
C18H14N2O4
Numer CAS:
Masa cząsteczkowa:
322.31
Numer MDL:
Kod UNSPSC:
12352200
NACRES:
NA.77

Nazwa produktu

Dynamin Inhibitor I, Dynasore, The Dynamin Inhibitor I, Dynasore, also referenced under CAS 304448-55-3, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

Poziom jakości

Próba

≥98% (HPLC)

Formularz

solid

producent / nazwa handlowa

Calbiochem®

warunki przechowywania

OK to freeze
protect from light

kolor

pale yellow

rozpuszczalność

DMSO: 16 mg/mL

Warunki transportu

ambient

temp. przechowywania

2-8°C

ciąg SMILES

N(\N=C\c3cc(c(cc3)O)O)C(=O)c1cc2c(cc1O)cccc2

InChI

1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+

Klucz InChI

SYNDQCRDGGCQRZ-VXLYETTFSA-N

Opis ogólny

A cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane.

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Environmental Hazard (N)

Rekonstytucja

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Inne uwagi

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Young, A., et al. 2009. Biochem. J., In press.
Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol.16, 607.
Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA103, 17955.
Macia. E., et al. 2006. Dev. Cell10, 839.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

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