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235420

Sigma-Aldrich

Caspase-3 Inhibitor I

The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

Synonim(y):

Caspase-3 Inhibitor I, CPP32/Apopain Inhibitor, Ac-DEVD-CHO

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About This Item

Wzór empiryczny (zapis Hilla):
C20H30N4O11
Numer CAS:
169332-60-9
Masa cząsteczkowa:
502.47
Numer MDL:
MFCD00671412
Kod UNSPSC:
12352200
NACRES:
NA.77

Poziom jakości

100

Próba

≥90% (HPLC)

Postać

solid

producent / nazwa handlowa

Calbiochem®

warunki przechowywania

OK to freeze

kolor

white

rozpuszczalność

DMSO: 5 mg/mL
water: soluble

Warunki transportu

ambient

temp. przechowywania

−20°C

InChI

1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)/t11-,12-,13-,17-/m0/s1

Klucz InChI

UMBVAPCONCILTL-MRHIQRDNSA-N

Opis ogólny

A specific and reversible inhibitor of CPP32/Apopain/Yama (IC50 = 0.2 nM). A member of the ICE/CED-3 family of cysteine proteases, which are important in apoptosis.
A very potent, specific, and reversible inhibitor of caspase-3 (IC50 = 200 pM), caspase-6, caspase-7, caspase-8, and caspase-10.

Działania biochem./fizjol.

Cell permeable: no
Primary Target
Capase-3, capase-6, capase-7, capase-8, capase-10
Product does not compete with ATP.
Reversible: yes
Target IC50: 200 pM against caspase-3

Opakowanie

Yes

Ostrzeżenie

Toxicity: Standard Handling (A)

Sekwencja

Ac-Asp-Glu-Val-Asp-CHO

Rekonstytucja

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Inne uwagi

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature376, 37.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

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