204883

Complement C1-Esterase Inhibitor, Human

Complement C1-Esterase Inhibitor, Human, is a native, single-chain glycoprotein that is involved in regulation of complement, coagulation, fibrinolytic and contact systems of circulating plasma.

• Kod UNSPSC: 12352202
• NACRES: NA.25

Właściwości

• Poziom jakości: 100
• Próba: ≥90% (SDS-PAGE)
• Formularz: liquid
• nie zawiera: preservative
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; avoid repeated freeze/thaw cycles
• zanieczyszczenia: IgG, IgA, IgM, albumin, C3, C4, or ceruloplasmin, trace
• Warunki transportu: wet ice
• temp. przechowywania: −70°C

Opis

Opis ogólny

Native, human C1-esterase. Complent C1-esterase inhibitor purified from human plasma. Single chain glycoprotein present in normal human serum at a concentration of 180 µg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. It is the only known inhibitor of activated C1r and C1s complement enzymes. Persons with either hereditary or acquired deficiencies of C1 esterase inhibitor are susceptible to recurrent attacks of angioedema.

Native, human C1-esterase. Single-chain glycoprotein present in normal human serum at 180 µg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. The only known inhibitor of activated C1r and C1s complement enzymes. The presence of either hereditary or acquired deficiencies of C1 inhibitor produce susceptibility to recurrent attacks of angioedema.

Działania biochem./fizjol.

≥80% of C1-esterase inhibitor will bind activated C1s.

Opakowanie

Please refer to vial label for lot-specific concentration.

Ostrzeżenie

Toxicity: Standard Handling (A)

Postać fizyczna

In PBS, pH 7.4, sterile-filtered through a 0.22 µm filter.

Uwaga dotycząca przygotowania

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Rekonstytucja

Following initial thaw, aliquot and freeze (-70°C).

Inne uwagi

Bowen, B., et al. 2001. Clin. Immunol.98, 157.
Davis, A.E. 1988. Ann. Rev. Immunol. 6, 595.

Variables associated with assay conditions will dictate the proper working dilution.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable