178251

_{α1-antytrypsyna}, ludzkie osocze

α₁-Antitrypsin, CAS 9041-92-3, is a protease inhibitor of the serpin superfamily. Inhibits elastase, cathepsin G, and proteinase 3.

• Synonim(y): α₁-AT, inhibitor α₁-proteinazy, 3,5S α₁-glikoproteina
• Numer CAS: 9041-92-3
• Numer MDL: MFCD00130469
• Kod UNSPSC: 12352202
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• opis: Merck USA index - 14, 719
• Próba: ≥95% (SDS-PAGE)
• Formularz: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze
• rozpuszczalność: water: soluble
• Warunki transportu: ambient
• temp. przechowywania: −20°C

Opis

Opis ogólny

A single polypeptide chain of 394 amino acids and three carbohydrate side chains linked to asparagine residues present at about 290 mg/100 ml in acute phase plasma. Serine protease inhibitor that also acts as a major physiological regulator of elastase. Inhibitor of neutrophil elastase, cathepsin G, and proteinase 3.

Działania biochem./fizjol.

Cell permeable: no

Primary Target
serine proteases

Product does not compete with ATP.

Reversible: no

Ostrzeżenie

Toxicity: Standard Handling (A)

Postać fizyczna

Lyophilized from 300 mM NaCl, 30 mM sodium phosphate buffer, pH 6.5.

Uwaga dotycząca przygotowania

Please refer to vial label for lot-specific volume prior to lyophilization.

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Rekonstytucja

Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.

Komentarz do analizy

>=75% inhibition with active-site titrated porcine trypsin using benzoyl-Arg-p-nitroanilide (Bz-Arg-pNA) as the substrate.

Inne uwagi

Coakley, R.J., et al. 2001. Am. J. Med. Sci.321, 33.
Travis, J., and Salvesen, G.S. 1983. Annu. Rev. Biochem.52, 655.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Oświadczenie o zrzeczeniu się odpowiedzialności

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable