124015

Akt Inhibitor IV

InSolution, ≥98%

• Synonim(y): InSolution Akt Inhibitor IV
• Wzór empiryczny (zapis Hilla): C₃₁H₂₇IN₄S
• Masa cząsteczkowa: 614.54
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥98% (HPLC)
• Postać: liquid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; desiccated (hygroscopic); protect from light
• Warunki transportu: wet ice
• temp. przechowywania: 2-8°C

Opis

Opis ogólny

A cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activation presumably by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC₅₀ = 625 nM) and cell proliferation (IC₅₀<1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K.

Działania biochem./fizjol.

Cell permeable: yes

Primary Target
Akt

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 625 nM and <1.25 µM in blocking Akt-mediated FOXO1a nuclear export and cell proliferation, respectively, in 786-O cells

Opakowanie

Packaged under inert gas

Please refer to vial label for lot-specific concentration.

Ostrzeżenie

Toxicity: Irritant (B)

Postać fizyczna

A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124011) in DMSO.

Rekonstytucja

Following initial use, aliquot and refrigerate (4°C).

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

This page may contain text that has been machine translated.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Temperatura zapłonu (°C): 87 °C - closed cup - (Dimethylsulfoxide)