1.07185

Pepsin

(from porcine gastric mucosa) 0.7 FIP-U/mg for biochemistry EC 3.4.23.1

• Synonim(y): Pepsin
• Numer CAS: 9001-75-6
• Masa cząsteczkowa: 35000
• Numer MDL: MFCD00081840
• Kod UNSPSC: 12352204
• Numer indeksu EC: 232-629-3
• NACRES: NA.21

Właściwości

• pH: 4.0-5.0 (20 °C, 10 g/L in H₂O)
• rozpuszczalność: 10 g/L
• gęstość nasypowa: 380‑420 kg/m³
• temp. przechowywania: 2-30°C

Opis

Zastosowanie

Pepsin has been used in the preparation of simulated gastric fluid to perform in vitro gastric digestion.

Działania biochem./fizjol.

Pepsin is a component of gastric juice and is associated with protein digestion. It is an endopeptidase that catalyzes the degradation of proteins into peptides and amino acids for small intestinal absorption. Pepsin is released as a zymogen (pepsinogen) by the chief cells of the gastric lining. It gets activated by the acidic environment created by the hydrochloric acid (HCl) of gastric juice. Pepsin is active at pH 1.5 to 2, in the stomach. It is involved in the conversion of food bolus into chyme. It is associated with laryngopharyngeal reflux (LPR) indicated by chronic cough, mild dysphagia, hoarseness, and non-productive throat clearing.

Komentarz do analizy

Appearance: fine, slightly yellow powder
Activity/FIP (Hemoglobin; pH 1.6; 25 °C): ≥ 0.70 FIP-U/mg
pH-value (1 %; water): 4.0 - 5.0
Water (according to Karl Fischer): ≤ 6.0 %

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H315 - H319 - H334 - H335
• Zwroty wskazujące środki ostrożności: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• Organy docelowe: Respiratory system
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable