1.00164

Boric acid

cryst., EMPROVE^® API, Ph. Eur., BP, NF

• Synonim(y): Orthoboric acid, Trihydroxidoboron
• Wzór liniowy: H₃BO₃
• Numer CAS: 10043-35-3
• Masa cząsteczkowa: 61.83
• Numer MDL: MFCD00011337
• Kod UNSPSC: 12352106
• Numer indeksu EC: 233-139-2

Właściwości

• agency: BP; NF; Ph. Eur.
• Poziom jakości: 600
• ciśnienie pary: 2.6 mmHg ( 20 °C)
• linia produktu: EMPROVE^® API
• Próba: 99.5-100.5% (alkalimetric)
• Postać: solid
• siła działania: 2660 mg/kg LD₅₀, oral (Rat); >2000 mg/kg LD₅₀, skin (Rat)
• pH: 3.8-4.8 (20 °C, 33 g/L in H₂O)
• mp: 160 °C (dec.) (lit.)
• rozpuszczalność: 49.2 g/L
• gęstość: 1.489 g/cm³ at 23 °C
• gęstość nasypowa: 400‑600 kg/m³
• ślady anionów: sulfate (SO₄^2-): ≤0.04%
• ślady kationów: As: ≤0.0001%; heavy metals (as Pb): ≤0.0015%
• Zastosowanie: liquid formulation; ophthalmics; parenterals; pharmaceutical; semi-solid formulation
• temp. przechowywania: 2-25°C
• ciąg SMILES: OB(O)O
• InChI: 1S/BH3O3/c2-1(3)4/h2-4H
• Klucz InChI: KGBXLFKZBHKPEV-UHFFFAOYSA-N

Opis

Opis ogólny

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Zastosowanie

Boric acid as an active ingredient is used in ophthalmic drugs, as antiseptic for cuts and burns, as well as antibacterial for dermatological treatments such as acne and athlete foot. Boric acid Emprove^® API is manufactured according to ICH Q7 guidelines. A CEP and an US-DMF are available.

Informacje prawne

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H360FD
• Zwroty wskazujące środki ostrożności: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Klasyfikacja zagrożeń: Repr. 1B
• Kod klasy składowania: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable