09-078

Anti-EHMT1/GLP1 Antibody

Upstate^®, from rabbit

• Synonim(y): G9a like protein, H3-K9-HMTase, Histone H3-K9 methyltransferase, Histone-lysine N-methyltransferase, H3 lysine-9 specific, EC 2.1.1.43, euchromatic histone methyltransferase 1, euchromatic histone-lysine N-methyltransferase 1, Eu-HMTase1, FLJ12879 1, FP1
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• forma przeciwciała: affinity purified immunoglobulin
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• oczyszczone przez: affinity chromatography
• reaktywność gatunkowa: human
• producent / nazwa handlowa: Upstate^®
• metody: western blot: suitable
• izotyp: IgG
• numer dostępu NCBI: NM_012117.1
• numer dostępu UniProt: Q9H9B1
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... EHMT1(79813)

Opis

Opis ogólny

G9a-Like Protein 1 (GLP1), also known as Euchromatic histone lysine N-methyl-transferase 1 (EMHT1), is a histone methyltransferase that methylates Lys9 of histone H3. H3Lys9 methylation is a marker for epigenetic transcriptional repression. EMHT1/GLP1 is targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it contributes to silencing of Myc- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. EMHT1/GLP1 is phosphorylated upon DNA damage, probably by ATM or ATR. Defects in EHMT1 result in severe mental retardation, hypotonia, and epileptic seizures.

Specyficzność

Recognizes EMHT1/GLP1

Immunogen

Epitope: a.a. 40-59

KLH conjugated synthetic peptide (KHTQDSARVNPQDGTNTLTR(C) corresponding to a.a. 40-59 of human EMHT1/GLP1.

Zastosowanie

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Chromatin Biology

Histones

Use Anti-EHMT1/GLP1 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect EHMT1/GLP1 also known as H3-K9-HMTase 5, Histone H3-K9 methyltransferase 5.

Jakość

Routinely evaluated by immunoblot.

Opis wartości docelowych

160 kda

Postać fizyczna

ImmunoAffinity Purified

Immunoaffinity purified rabbit IgG in PBS containing 0.1% sodium azide, 30% glycerol

Przechowywanie i stabilność

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informacje prawne

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 2