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Key Documents

07-2274

Sigma-Aldrich

Anti-FSP1/S100A4 Antibody

from rabbit

Synonim(y):

S100 calcium binding protein A4, S100 calcium-binding protein A4, fibroblast-specific protein-1, leukemia multidrug resistance associated protein, S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog), malig

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About This Item

Kod UNSPSC:
12352203
eCl@ss:
32160702

pochodzenie biologiczne

rabbit

Poziom jakości

rodzaj przeciwciała

primary antibodies

klon

polyclonal

reaktywność gatunkowa

mouse, human

metody

immunohistochemistry: suitable (paraffin)
western blot: suitable

izotyp

IgG

numer dostępu NCBI

numer dostępu UniProt

Warunki transportu

wet ice

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... S100A4(6275)
mouse ... S100A4(20198)

Opis ogólny

Fibroblast-specific protein-1 (FSP1)/S100A4 is a cytoplasmic calcium-binding protein belonging to the S100 superfamily of which at least 21 members have been identified so far. Researchers believe that FSP1/S1004A is highly expressed in fibroblasts (Iwano et al., 2001; Strutz et al., 1995), in epithelial and endothelial cells undergoing epithelial-mesenchymal transition (EMT) (Iwano et al., 2002; Zeisberg and Neilson, 2009), and epithelial cancer cells that complete a transition to a metastatic phenotype (Xue et al., 2003).

Immunogen

Epitope: Unknown
Histidine-tagged recombinant protein corresponding to mouse FSP1/S100-A4.

Zastosowanie

Detect the FSP1/S100A4 protein using this Anti-FSP1/S100A4 validated for use in WB & IHC.
Research Category
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
Western Blot Analysis: 1 µg/mL from a previous lot detected S100-A4 on 10 µg of HeLa cell lysate.

Jakość

Evaluated by Western Blot in NIH/3T3 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected FSP1/S100-A4 on 10 µg of NIH/3T3 cell lysate.

Opis wartości docelowych

~ 12 kDa

Postać fizyczna

Format: Purified
Protein G Purified
Purified rabbit polyclonal containing PBS with 0.05% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Komentarz do analizy

Control
NIH/3T3 cell lysate

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Thomas Bärnthaler et al.
The Journal of allergy and clinical immunology, 145(3), 818-833 (2019-12-10)
Idiopathic pulmonary fibrosis (IPF) is a disease with high 5-year mortality and few therapeutic options. Prostaglandin (PG) E2 exhibits antifibrotic properties and is reduced in bronchoalveolar lavage from patients with IPF. 15-Prostaglandin dehydrogenase (15-PGDH) is the key enzyme in PGE2
Xinyi Wang et al.
JCI insight, 5(12) (2020-05-13)
Renal fibrosis features exaggerated inflammation, extracellular matrix (ECM) deposition, and peritubular capillary loss. We previously showed that IL-10 stimulates high-molecular weight hyaluronan (HMW-HA) expression by fibroblasts, and we hypothesize that HMW-HA attenuates renal fibrosis by reducing inflammation and ECM remodeling.
Elizabeth F Redente et al.
JCI insight, 6(1) (2020-12-09)
Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible fibrotic disease of the distal lung alveoli that culminates in respiratory failure and reduced lifespan. Unlike normal lung repair in response to injury, IPF is associated with the accumulation and persistence of
Meiling Melzer et al.
Journal of visualized experiments : JoVE, (157) (2020-04-01)
Cardiac fibrosis in response to injury is a physiological response to wound healing. Efforts have been made to study and target fibroblast subtypes that mitigate fibrosis. However, fibroblast research has been hindered due to the lack of universally acceptable fibroblast
Jiyoung Lee et al.
Scientific reports, 11(1), 14950-14950 (2021-07-24)
The inflammatory chemokines, monocyte chemoattractant protein (MCP)-1 and IL-8, are produced by normal trabecular meshwork cells (TM) and elevated in the aqueous humor of primary open angle glaucoma (POAG) and hypertensive anterior uveitis associated with viral infection. However, their role

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