05-521
Anti-TRF2 Antibody, clone 4A794
clone 4A794, Upstate®, from mouse
Synonim(y):
Anti-TRBF2, Anti-TRF2
Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
About This Item
Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Polecane produkty
pochodzenie biologiczne
mouse
Poziom jakości
forma przeciwciała
purified immunoglobulin
rodzaj przeciwciała
primary antibodies
klon
4A794, monoclonal
reaktywność gatunkowa
rat, human
producent / nazwa handlowa
Upstate®
metody
immunocytochemistry: suitable
western blot: suitable
izotyp
IgG1
numer dostępu NCBI
numer dostępu UniProt
Warunki transportu
dry ice
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... TERF2(7014)
Opis ogólny
TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localised to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types. TRF2 is overexpressed in a number of human tumors and overexpression of TRF2 has been shown to be oncogenic in a mouse model of carcinogenesis.
Specyficzność
Recognizes TRF2.
Immunogen
His-tagged, fusion-protein, corresponding to full-length TRF2 (Telomeric Repeat binding Factor 2), expressed in baculovirus
Zastosowanie
Anti-TRF2 Antibody, clone 4A794 is a Mouse Monoclonal Antibody for detection of TRF2 also known as Telomeric repeat-binding factor 1 & has been tested in ICC & WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair
Cell Cycle, DNA Replication & Repair
Jakość
routinely evaluated by immunoblot on RIPA lysate of human Jurkat cells, HeLa nuclear extract, or rat L6 RIPA cell lysate
Opis wartości docelowych
66 kDa
Postać fizyczna
Format: Purified
Protein G Purified
Protein G Purified mouse IgG1 in PBS with 0.05% sodium azide.
Przechowywanie i stabilność
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Komentarz do analizy
Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
Informacje prawne
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
S K Manna et al.
Journal of immunology (Baltimore, Md. : 1950), 165(9), 4927-4934 (2000-10-25)
We and others have reported that IFN-alpha potentiates the apoptotic effects of TNF through a mechanism that is not understood. Because the nuclear transcription factors NF-kappaB and AP-1 have recently been reported to mediate anti-apoptosis and cell survival, we hypothesized
Manale El Idrissi et al.
Journal of experimental & clinical cancer research : CR, 32, 64-64 (2013-09-12)
Among the numerous genetic defects associated with hepatocarcinogenesis, telomere abnormalities appear to play a role both in tumor promotion and maintenance. Telomeres, the chromosome extremities, are protected by specific proteins, the shelterin complex and by additional factors. Besides telomerase dysregulation
Clara Lopes Novo et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(9), 3632-3642 (2013-06-05)
Telomeres are major regulators of genome stability and cell proliferation. A detailed understanding of the mechanisms involved in their maintenance is of foremost importance. Of those, telomere chromatin remodeling is probably the least studied; thus, we intended to explore the
Different telomere damage signaling pathways in human and mouse cells.
Agata Smogorzewska, Titia de Lange
The Embo Journal null
The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo.
Andre Lechel, Ande Satyanarayana, Zhenyu Ju, Ruben R Plentz, Sonja Schaetzlein et al.
EMBO Reports null
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