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Key Documents

880124X

Avanti

DSPE-PEG(2000) Folate

Avanti Research™ - A Croda Brand 880124X

Synonim(y):

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000] (ammonium salt):methanol (9:1)

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About This Item

Numer CAS:
1236288-25-7
Kod UNSPSC:
12352211
NACRES:
NA.25

Postać

liquid

opakowanie

pkg of 1 × 1 mL (880124X-10mg)
pkg of 1 × 1 mL (880124X-1mg)

producent / nazwa handlowa

Avanti Research™ - A Croda Brand 880124X

stężenie

1 mg/mL (880124X-1mg)
10 mg/mL (880124X-10mg)

Warunki transportu

dry ice

temp. przechowywania

−20°C

Opis ogólny

DSPE-PEG(2000) Folate, also known as 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000], is a functionalized PEG lipid. This lipid is added into liposomes as a targeting ligand for folate receptors, which acts as cellular surface markers for numerous solid tumors and myeloid leukemias. Folate targeted drug delivery is used an effective therapy for the treatment and imaging of various cancers and inflammatory diseases. Folate conjugates with low molecular weight and high binding affinity for folate receptors (FR) on cell surface deliver a variety of molecular complexes such as protein toxins, immune stimulants, chemotherapeutic agents, liposomes, nanoparticles, and imaging agents to pathologic cells without affecting normal tissues.

Zastosowanie

DSPE-PEG(2000) Folate(1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000]) may be used in preparation of folate-conjugated liposomes and folate-modified microvesicles (MVs).

Opakowanie

5 mL Clear Glass Sealed Ampule (880124X-10mg)
5 mL Clear Glass Sealed Ampule (880124X-1mg)

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC
This page may contain text that has been machine translated.

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H226,H302,H315,H319,H331,H336,H351,H361d,H371,H372

Klasyfikacja zagrożeń

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 2 - STOT SE 3

Organy docelowe

Eyes,Central nervous system, Liver,Kidney, Respiratory system

Kod klasy składowania

3 - Flammable liquids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

80.6 °F

Temperatura zapłonu (°C)

27 °C

Certyfikaty analizy (CoA)

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To establish a novel formulation tumor-targeted drug carrier of lipophilic antitumor antibiotics, aclacinomycin A (ACM), folate-linked microemulsions were prepared and investigated both in vitro and in vivo. Three kinds of folate-linked microemulsions with different polyethylene glycol (PEG) chain lengths loading
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