850185P

08:0 PI(4,5)P2

Avanti Research^™ - A Croda Brand

• Synonim(y): PIP2[4′,5′](8:0/8:0); 110665
• Wzór empiryczny (zapis Hilla): C₂₅H₅₈N₃O₁₉P₃
• Numer CAS: 852043-37-9
• Masa cząsteczkowa: 797.66
• Kod UNSPSC: 51191904
• NACRES: NA.25

Właściwości

• opis: 1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium salt)
• Próba: >99% (TLC)
• Formularz: powder
• opakowanie: pkg of 1 × 100 μg (with stopper and crimp cap (850185P-100ug)); pkg of 1 × 500 μg (with stopper and crimp cap (850185P-500ug))
• producent / nazwa handlowa: Avanti Research^™ - A Croda Brand
• typ lipidu: cardiolipins; phospholipids
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• ciąg SMILES: [H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+].[NH4+].[NH4+]
• InChI: 1S/C25H49O19P3.3H3N/c1-3-5-7-9-11-13-18(26)39-15-17(41-19(27)14-12-10-8-6-4-2)16-40-47(37,38)44-23-20(28)21(29)24(42-45(31,32)33)25(22(23)30)43-46(34,35)36;;;/h17,20-25,28-30H,3-16H2,1-2H3,(H,37,38)(H2,31,32,33)(H2,34,35,36);3*1H3/t17-,20-,21+,22+,23-,24-
• Klucz InChI: FRWPUPUJRUQWKA-OZTQGENFSA-N

Opis

Opis ogólny

Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT. The dioctanoyl derivative of PI(4,5)P2 is more water soluble than its long chain counterparts.

Zastosowanie

08:0 PI(4,5)P2 is suitable for use to identify its binding site in transient receptor potential vanilloid 4 (TRPV4 N) terminus. It has been used in in vitro binding assay to determine the binding of G-protein coupled receptor kinases (GRKs) and β2-adrenergic receptor (β₂AR).

Opakowanie

2 mL Amber Serum Vial with Stopper and Crimp Cap (850185P-100ug)

2 mL Amber Serum Vial with Stopper and Crimp Cap (850185P-500ug)

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids