934429

3-((4-(Piperidin-4-yl)phenyl)amino)piperidine-2,6-dione hydrochloride

≥95%

• Synonim(y): 3-((4-(Piperidin-4-yl)phenyl)amino)piperidine-2,6-dione hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₆H₂₁N₃O₂ · xHCl
• Masa cząsteczkowa: 287.36 (free base basis)
• Kod UNSPSC: 12352200

Właściwości

• Poziom jakości: 100
• Próba: ≥95%
• Postać: powder
• temp. przechowywania: 2-8°C
• ciąg SMILES: O=C1NC(C(NC2=CC=C(C=C2)C3CCNCC3)CC1)=O.[xHCl]

Opis

Zastosowanie

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

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Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Inne uwagi

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

Informacje prawne

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable