ELANE
elastase, neutrophil expressed
Synonimy:
ELA2, GE, HLE, HNE, NE, PMN-E, SCN1
Gatunek:
Human ELANE (1991), Mouse Elane (50701), Rat Elane (299606), sheep ELANE (101110841), domestic guinea pig Elane (100724414), cow ELANE (100126050), Horse ELANE (100462967), domestic cat ELANE (100301482), dog ELANE (442980)
Identyfikator UniProtKB:
Identyfikator genu:
- Human(1991) Summary: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]
- Mouse(50701) elastase, neutrophil expressed
- Rat(299606) elastase, neutrophil expressed
- sheep(101110841) elastase, neutrophil expressed
- domestic guinea pig(100724414) elastase, neutrophil expressed
- cow(100126050) elastase, neutrophil expressed
- Horse(100462967) elastase, neutrophil expressed
- domestic cat(100301482) elastase, neutrophil expressed
- dog(442980) elastase, neutrophil expressed
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Anti-Neutrophil Elastase (ELANE) Antibody, clone 8X4E6, Rabbit Monoclonal, ,
Reaktywność gatunkowa
mouse
Zastosowanie
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-Elane Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
Anti-ELANE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
ANTI-NEUTROPHIL ELASTASE(N-TERMINAL) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
western blot
Anti-Neutrophil Elastase antibody, Rabbit monoclonal, clone SP203, recombinant, expressed in proprietary host, affinity isolated antibody,
Reaktywność gatunkowa
human
Zastosowanie
immunohistochemistry
Proteins
esiRNA
Numer produktu
Opis
Gatunek