W4262

1400W dihydrochloride

>98%, solid

• 동의어(들): N-([3-(Aminomethyl)phenyl]methyl)ethanimidamide dihydrochloride
• 실험식(Hill 표기법): C₁₀H₁₅N₃ · 2 HCl
• CAS Number: 214358-33-5
• Molecular Weight: 250.17
• MDL number: MFCD03428622
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278778
• NACRES: NA.77

속성

• 분석: >98%
• 양식: solid
• 저장 조건: desiccated
• 주관자: GlaxoSmithKline
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: Cl[H].Cl[H].CC(=N)NCc1cccc(CN)c1
• InChI: 1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
• InChI key: WDJHSQZCZGPGAA-UHFFFAOYSA-N
• 유전자 정보: human ... NOS1(4842) , NOS2(4843) , NOS3(4846)

설명

애플리케이션

1400W dihydrochloride has been used:

• as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat
• as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction
• to study its efficacy on renal ischemia/ reperfusion injury in rats
• as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation

생화학적/생리학적 작용

1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS).

특징 및 장점

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)