M7033

N^G-Methyl-L-arginine acetate salt

≥98% (TLC), powder, nitric oxide synthase inhibitor

• 동의어(들): N_ω-Methyl-L-arginine acetate salt, L-NMMA, N⁵-(Methylamidino)-L-ornithine acetate salt, N^G-Monomethyl-L-arginine acetate salt
• 실험식(Hill 표기법): C₇H₁₆N₄O₂ · C₂H₄O₂
• CAS Number: 53308-83-1
• Molecular Weight: 248.28
• Beilstein: 6674255
• MDL number: MFCD00069311
• UNSPSC 코드: 12352209
• PubChem Substance ID: 24278043
• NACRES: NA.77

속성

• product name: N^G-Methyl-L-arginine acetate salt, ≥98% (TLC)
• Quality Level: 200
• 분석: ≥98% (TLC)
• 형태: powder
• solubility: water: 49.00-51.00 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• SMILES string: CC(O)=O.CNC(=N)NCCC[C@H](N)C(O)=O
• InChI: 1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
• InChI key: IKPNWIGTWUZCKM-JEDNCBNOSA-N
• 유전자 정보: human ... NOS1(4842) , NOS2(4843) , NOS3(4846) ; mouse ... Nos2(18126) ; rat ... Nos1(24598) , Nos2(24599)

설명

애플리케이션

N^G-Methyl-L-arginine acetate salt has been used:

• as an inhibitor of nitric oxide synthase (NOS) in wound healing studies in injured mice
• as an inhibitor of nitric oxide synthase (NOS) to study nitric oxide (NO) immunosuppressive effect of murine stem cells
• as an inhibitor to monitor NO levels in hemocytes respiratory burst assay

생화학적/생리학적 작용

N^G-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages. It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine. It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system.

특징 및 장점

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)