T4014

Tobramycin

Aminoglycoside antibiotic

• 동의어(들): 3′-Deoxykanamycin B, Nebramycin Factor 6, O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine
• 실험식(Hill 표기법): C₁₈H₃₇N₅O₉
• CAS Number: 32986-56-4
• Molecular Weight: 467.51
• Beilstein: 1357507
• EC Number: 251-322-5
• MDL number: MFCD00077885
• UNSPSC 코드: 51281626
• PubChem Substance ID: 24900188
• NACRES: NA.85

속성

• 생물학적 소스: Streptomyces tenebrarius
• Quality Level: 200
• 양식: powder
• 저장 조건: (Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
• 농도: ≥900 μg/mg (anhydrous)
• 색상: white to off-white
• 항생제 활성 스펙트럼: Gram-negative bacteria
• 동작 모드: protein synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
• InChI: 1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1
• InChI key: NLVFBUXFDBBNBW-SNGYORCQSA-N

설명

일반 설명

Chemical structure: aminoglycoside

Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the Pseudomonas species.

애플리케이션

Tobramycin has been used:

• to study the effect of tobramycin on bacteriophage infected biofilms
• to study the effects of antibiotics on Pseudomonas aeruginosa strain
• as a comparator antibiotic

생화학적/생리학적 작용

Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16S rRNA (ribosomal RNA). It inhibits translocation and elicits miscoding.
Tobramycin is used to treat Pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis, and other soft-tissue infections. It is a potential therapy for sinus infections.

Tobramycin is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.

기타 정보

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

안전성 정보

• 픽토그램: GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H361f
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3