추천 제품
생물학적 소스
human
재조합
expressed in E. coli
분석
≥90% (SDS-PAGE)
양식
liquid
분자량
54.5 kDa
포장
pkg of 100 μg
NCBI 수납 번호
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... ALDH2(217)
일반 설명
ALDH2 (Aldehyde dehydrogenase 2 family) belongs to the aldehyde dehydrogenase family which catalyze the chemical transformation from acetaldehyde to acetic acid and is the second enzyme of the major oxidative pathway of alcohol metabolism. There are two major liver isoforms of this enzyme, cytosolic and mitochondrial, and they can be also distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. ALDH2 has been shown to interact with GroEL.
The ALDH2 gene is mapped to human chromosome 12q24.12.
생화학적/생리학적 작용
Aldehyde dehydrogenases catalyze the chemical transformation from acetaldehyde to acetic acid and ALDH2 (Aldehyde dehydrogenase 2 family) is the major enzyme of the oxidative pathway of alcohol metabolism. Overexpression of ALDH2 inhibits cell injury induced by acetaldehyde and prevents activation of stress signals.
It is actively involved in the metabolism of both endogenous and exogenous substances.
물리적 형태
1 mg/mL solution in 20 mM Tris-HCl buffer (pH 7.5) containing 1 mM DTT, 1 mM EDTA and 10% glycerol.
제조 메모
Centrifuge the vial prior to opening.
기타 정보
MSAAATQAVP APNQQPEVFC NQIFINNEWH DAVSRKTFPT VNPSTGEVIC QVAEGDKEDV DKAVKAARAA FQLGSPWRRM DASHRGRLLN RLADLIERDR TYLAALETLD NGKPYVISYL VDLDMVLKCL RYYAGWADKY HGKTIPIDGD FFSYTRHEPV GVCGQIIPWN FPLLMQAWKL GPALATGNVV VMKVAEQTPL TALYVANLIK EAGFPPGVVN IVPGFGPTAG AAIASHEDVD KVAFTGSTEI GRVIQVAAGS SNLKRVTLEL GGKSPNIIMS DADMDWAVEQ AHFALFFNQG QCCCAGSRTF VQEDIYDEFV ERSVARAKSR VVGNPFDSKT EQGPQVDETQ FKKILGYINT GKQEGAKLLC GGGIAADRGY FIQPTVFGDV QDGMTIAKEE IFGPVMQILK FKTIEEVVGR ANNSTYGLAA AVFTKDLDKA NYLSQALQAG TVWVNCYDVF GAQSPFGGYK MSGSGRELGE YGLQAYTEVK TVTVKVPQKN S
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Significant association between decreased ALDH2 activity and increased sensitivity to genotoxic effects in workers occupationally exposed to styrene.
Weng Z, et al.
Oncotarget, 7(25), 38224-38224 (2016)
Aishwarya Nene et al.
Journal of biomedical science, 24(1), 3-3 (2017-01-07)
Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is a key enzyme for the metabolism of many toxic aldehydes such as acetaldehyde, derived from alcohol drinking, and 4HNE, an oxidative stress-derived lipid peroxidation aldehyde. Post-translational enhancement of ALDH2 activity can be achieved by
Overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene prevents acetaldehyde-induced cell injury in human umbilical vein endothelial cells: role of ERK and p38 mitogen-activated protein kinase.
Li SY
The Journal of Biological Chemistry, 279, 11244-11252 (2004)
Direct detection of usual and atypical alleles on the human aldehyde dehydrogenase-2 (ALDH2) locus
Hsu LC
American Journal of Human Genetics, 41, 996-1001 (1987)
Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2.
Hsu LC
Proceedings of the National Academy of Sciences of the USA, 82, 3771-3775 (1985)
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