SRP3327

IL-1 RECEPTOR ANTAGONIST human

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

• 동의어(들): ICIL-1RA, IL-1RN, IL-1Ra, IRAP
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥98% (HPLC); ≥98% (SDS-PAGE)
• 형태: lyophilized
• 효능: 20-40 ng/mL
• 분자량: 17.2 kDa
• 포장: pkg of 100 μg
• 저장 조건: (Keep container tightly closed in a dry and well-ventilated place)
• 기술: activity assay: suitable
• 불순물: endotoxin, tested
• 색상: white to off-white
• UniProt 수납 번호: P14778
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... IL1R1(3554)

설명

일반 설명

Research area: Immunology & cytokines

Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Recombinant human IL-1Ra is a 17.2kDa protein consisting of 153 amino acid residues.

애플리케이션

Interleukin-1 receptor antagonist (IL-1RA) human has been used:

• to study the role of interleukin (IL)-1β receptor in cell senescence induced by doxorubicin
• to block the IL-1β binding to its receptor
• to understand the role of autocrine interleukin-1β (IL-1β) signaling downstream of cl- in RPS27 modulation

생화학적/생리학적 작용

Interleukin-1 receptor antagonist (IL-1RA) inhibits the activity of IL-1α and IL-1β by competitively blocking binding to their type I and type II receptors. Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.

물리적 형태

Lyophilized from 20 mM Tris, pH 8.0.

재구성

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable