추천 제품
생물학적 소스
mouse
재조합
expressed in E. coli
분석
≥98% (SDS-PAGE)
형태
lyophilized
분자량
17.4 kDa
포장
pkg of 50 μg
기술
activity assay: suitable
불순물
Endotoxin, tested
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
mouse ... IL-1RA(16181)
일반 설명
Research area: IMMUNO AND CKS
Interleukin-1 receptor antagonist (IL-1 RA) is a member of the interleukin 1 cytokine family. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL-1RA mouse recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1RA is purified by proprietary chromatographic techniques. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2.
Interleukin-1 receptor antagonist (IL-1 RA) is a member of the interleukin 1 cytokine family. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL-1RA mouse recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1RA is purified by proprietary chromatographic techniques. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2.
Interleukin-1 RA is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL1 ra Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1RA is purified by proprietary chromatographic techniques.
애플리케이션
IL-1RA murine has been used as an antagonist to the interleukin-1 receptor in fibroblasts.
생화학적/생리학적 작용
Interleukin-1 receptor antagonist (IL-1Ra) protein mediates the inhibition of interleukin 1-α (IL1A) and interleukin 1-β (IL1B) activities. It is also involved in the modulation of IL-1 related immune and inflammatory responses. A polymorphism in the IL-1Ra gene is reported to be associated with an increased risk of osteoporotic fractures and gastric cancer. IL-1Ra is effective in treating bronchopulmonary dysplasia in murine models.This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B) and modulates a variety of interleukin 1 related immune and inflammatory responses.
물리적 형태
Lyophilized from H?O containing NaHCO?
재구성
Centrifuge the vial prior to opening. Reconstitute in sterile ddH?O to a concentration ? 100 μg/ml. This solution can then be diluted into other aqueous buffers.
기타 정보
The IL1RA is purified by proprietary chromatographic techniques.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Athanasios Didangelos et al.
Scientific reports, 6, 21607-21607 (2016-02-24)
Spinal cord injury is characterized by acute cellular and axonal damage followed by aggressive inflammation and pathological tissue remodelling. The biological mediators underlying these processes are still largely unknown. Here we apply an innovative proteomics approach targeting the enriched extracellular
W P Arend et al.
Annual review of immunology, 16, 27-55 (1998-05-23)
The interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family that binds to IL-1 receptors but does not induce any intracellular response. Two structural variants of IL-1Ra have previously been described: a 17-kDa form that is secreted from
B L Langdahl et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 15(3), 402-414 (2000-04-06)
Interleukin-1beta (IL-1beta) is a potent stimulator of bone resorption, and has been implicated in the pathogenesis of high bone turnover and osteoporosis. IL-1 receptor antagonist (IL-1ra) is a competitive inhibitor of IL-1beta effects and the biological effects of IL-1beta are
Hui Zhao et al.
Journal of neuroinflammation, 8, 159-159 (2011-11-15)
Neuroimmune modulation following traumatic stress is accompanied by cortical upregulation of c-Src expression, but the mechanistic details of the potential regulatory link between c-Src expression and immunosuppression have not been established. We used a combination of techniques to measure temporal
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