추천 제품
생물학적 소스
human
재조합
expressed in HEK 293 cells
분석
≥95% (HPLC)
≥95% (SDS-PAGE)
형태
lyophilized
분자량
30.0-33.0 kDa
포장
pkg of 20 μg
기술
cell culture | mammalian: suitable
불순물
<0.1 EU/μg endotoxin, tested
색상
white
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... VEGFC(7424)
일반 설명
Vascular endothelial growth factor-C (VEGF-C) is a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. It forms cell surface-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. Recombinant human VEGF-C is a 13.5kDa disulfide linked homodimeric protein consisting of two 116 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 30.0-33.0 kDa band by SDS-PAGE analysis under non-reducing condition.
생화학적/생리학적 작용
Vascular endothelial growth factor-C (VEGF-C) is a potent angiogenic factor. It promotes endothelial cell growth, lymphangiogesis and can also affect vascular permeability. VEGF-C can bind and activate both vascular endothelial growth factor receptors-2 and -3 (also known as flk1 and flt4 respectively). During embryogenesis, the protein may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis.
서열
AHYNTEILKS IDNEWRKTQC MPREVCIDVG KEFGVATNTF FKPPCVSVYR CGGCCNSEGL QCMNTSTSYL SKTLFEITVP LSQGPKPVTI SFANHTSCRC MSKLDVYRQV HSIIRR
물리적 형태
Lyophilized with no additives.
재구성
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. Avoid repeated freeze-thaw cycles.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Himadri Roy et al.
FEBS letters, 580(12), 2879-2887 (2006-04-25)
Angiogenesis is the process by which new blood vessels are formed from existing vessels. The vascular endothelial growth factors (VEGFs) are considered as key molecules in the process of angiogenesis. The VEGF family currently includes VEGF-A, -B, -C, -D, -E
Ellen C Breen
Journal of cellular biochemistry, 102(6), 1358-1367 (2007-11-06)
Vascular endothelial growth factor A (VEGF-A) belongs to a family of heparin binding growth factors that include VEGF-B, VEGF-C, VEGF-D, and placental-like growth factor (PLGF). First discovered for its ability to regulate vascular endothelial cell permeability, VEGF is a well-known
Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis.
Nagy JA
The Journal of Experimental Medicine, 196(11), 1497-1506 (2002)
Vascular endothelial growth factor-C (VEGF-C) and its receptors KDR and flt-4 are expressed in AIDS-associated Kaposi's sarcoma.
Skobe M
The Journal of Investigative Dermatology, 113(6), 1047-1053 (1999)
Vascular endothelial growth factor (VEGF)-A165-induced prostacyclin synthesis requires the activation of VEGF receptor-1 and -2 heterodimer.
Neagoe PE
The Journal of Biological Chemistry, 280(11), 9904-9912 (2005)
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