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V7259

Sigma-Aldrich

Vascular Endothelial Growth Factor human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, powder, suitable for cell culture

동의어(들):

VEGF

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About This Item

CAS Number:
127464-60-2
MDL number:
MFCD00286542
UNSPSC 코드:
12352202
NACRES:
NA.77

product name

Vascular Endothelial Growth Factor human, VEGF, recombinant, expressed in E. coli, powder, suitable for cell culture

생물학적 소스

human

Quality Level

200

재조합

expressed in E. coli

분석

≥98% (SDS-PAGE)

형태

powder

효능

1-10 ng/mL ED50/EC50

품질

endotoxin tested

분자량

protein 38.2 kDa (as homodimer)

포장

pkg of 10 μg

저장 조건

avoid repeated freeze/thaw cycles

기술

cell culture | mammalian: suitable

불순물

≤0.1 EU/μg

색상

white

solubility

water: soluble

UniProt 수납 번호

P15692

저장 온도

−20°C

유전자 정보

human ... VEGFA(7422)

일반 설명

Vascular Endothelial Growth Factor (VEGF) gene is localized to human chromosome 6p21.3, and is thought to encode four different isoforms.

애플리케이션

Vascular Endothelial Growth Factor (VEGF) has been used for-
  • the determination of oligodendrocyte precursor cells (OPCs) and luteal cell proliferation/survival
  • inducing proliferation of epithelial cell clusters (ECCs) to be transplanted into mice

생화학적/생리학적 작용

Vascular Endothelial Growth Factor (VEGF), also known as vasculotropin, is an angiogenic growth factor, which is heat and acid stable. VEGFs stimulate endothelial cell growth, angiogenisis, and capillary permeability. VEGF is a secreted homodimeric, heparin-binding glycoprotein,1 which has an isoelectric point of 8.5. VEGF promotes the growth of endothelial cells isolated from bovine adrenal cortex, cerebral cortex, fetal and adult aorta, and human umbilical vein. The target cell specificity of VEGF is restricted to vascular endothelial cells. VEGF has no mitogenic effect on cultured corneal endothelial cells, vascular smooth muscle cells, BHK-12 fibroblasts, keratinocytes, human sarcoma cells, or lens epithelial cells. A variety of human tumor cell lines including sarcoma and carcinoma cells show a 3.7 kb RNA transcript that hybridizes with the VEGF probe in a Northern blot. Mouse sarcoma 180 cells express the VEGF mRNA and secrete a VEGF-like mitogen.

VEGF recombinant protein might have potential as a therapeutic agent in treatment-resistant disorders, where it can facilitate endothelial cell growth and vessel formation.

물리적 특성

Monomer consists of 165 amino acid residues, approx. mol. weight 19.2 kDa

물리적 형태

Lyophilized from a sterile filtered buffered solution with no additives.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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이미 열람한 고객

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VEGF-B human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Sigma-Aldrich

SRP3183

VEGF-B human

Sigma-Aldrich

Sigma-Aldrich

SRP4037

FGF-2 human

VEGF-C human recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Sigma-Aldrich

SRP4633

VEGF-C human

Behrous Davani et al.
Stem cells (Dayton, Ohio), 25(12), 3215-3222 (2007-09-29)
Islet transplantation offers improved glucose homeostasis in diabetic patients, but transplantation of islets is limited by the supply of donor pancreases. Undifferentiated precursors hold promise for cell therapy because they can expand before differentiation to produce a large supply of
Chih-Hung Lai et al.
Frontiers in cell and developmental biology, 9, 635307-635307 (2021-03-02)
The homeostasis of vascular endothelium is crucial for cardiovascular health and endothelial cell (EC) aging and dysfunction could negatively impact vascular function. Leveraging transcriptome profiles from ECs subjected to various stimuli, including time-series data obtained from ECs under physiological pulsatile
Kazuhide Hayakawa et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(29), 10666-10670 (2011-07-22)
Originally identified as an angiogenic factor, vascular endothelial growth factor (VEGF-A) is now known to play multiple roles in the CNS, including the direct regulation of neuronal and astrocytic functions. Here, we ask whether VEGF-A can also have a novel
Michael Bressan et al.
Development (Cambridge, England), 141(21), 4149-4157 (2014-10-03)
Efficient blood flow depends on two developmental processes that occur within the atrioventricular junction (AVJ) of the heart: conduction delay, which entrains sequential chamber contraction; and valve formation, which prevents retrograde fluid movement. Defects in either result in severe congenital
The biology of vascular endothelial growth factor.
N Ferrara et al.
Endocrine reviews, 18(1), 4-25 (1997-02-01)
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문서

Vascular Endothelial Growth Factors (VEGF)

Vascular endothelial growth factor (VEGF) is a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGF-A (VEGF) is a potent growth factor for blood vessel endothelial cells, showing pleiotropic responses that facilitate cell migration, proliferation, tube formation, and survival. In the developing embryo VEGF-A mRNA is expressed by cells within tissues undergoing capillarization.

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

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