SRP0526

B7-1 (CD80), FC Fusion, Biotin Labeled

recombinant, expressed in HEK 293 cells

• 동의어(들): CTLA-4 Counter-Receptor B7.1
• UNSPSC 코드: 12352202
• NACRES: NA.26

속성

• 재조합: expressed in HEK 293 cells
• 형태: frozen liquid
• 분자량: 52.5 kDa
• UniProt 수납 번호: P33681
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... CD8O(941)

설명

일반 설명

CD80 or B7-1 is expressed in the antigen-presenting cells (APC). The CD80 gene is mapped to human chromosome 3q13.33.

Human secreted B7-1-Fc fusion protein, also known as CD80, with C-terminal Avitag^™ . GenBank Accession No. NM_005191, a.a 35-242 expressed in a HEK293 cell expression system and enzymatically biotin-labeled using Avitag^™ technology. MW = 52.5 kDa (monomer). This protein runs at a higher M.W. by SDS-PAGE due to glycosylation.

생화학적/생리학적 작용

CD80 is an efficient costimulatory molecule essential for immune surveillance during carcinogenesis. It inhibits cancer progression. It regulates the T cell activation to control immune response. Cell stress increases the CD80 expression. Reduced expression of CD80 is observed in colon carcinoma. High levels of CD80 stimulate anti-tumor immune responses. Therefore, enhancing CD80 expression in tumors might serve as a potent approach for cancer immunotherapy. Urinary CD80 is recognized as an important biomarker for idiopathic nephrotic syndrome (INS). CD80 might be involved in proteinuria, actin reorganization, and podocyte migration. Its expression in podocytes is associated with minimal change disease (MCD).

물리적 형태

Aqueous solution

법적 정보

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안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315 - H319
• 예방조치 성명서: P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1