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Merck
모든 사진(1)

Key Documents

SML2879

Sigma-Aldrich

TCS OX2 29 HCl

≥98% (HPLC)

동의어(들):

(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone HCl, (2S)-2-(4-Pyridylmethylamino)-1-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)-3,3-dimethylbutan-1-one HCl, TCS OX 229, TCS OX2 29, TCS-OX2-29, TCS-OX229, TCS-orexin 2-29

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C23H31N3O3 · xHCl
CAS Number:
372523-75-6
Molecular Weight:
397.51 (free base basis)
UNSPSC 코드:
12352200

Quality Level

100

분석

≥98% (HPLC)

형태

powder

저장 조건

desiccated

색상

white to beige

solubility

H2O: ≥2.0 mg/mL, clear

저장 온도

−20°C

InChI

1S/C23H31N3O3/c1-23(2,3)21(25-14-16-6-9-24-10-7-16)22(27)26-11-8-17-12-19(28-4)20(29-5)13-18(17)15-26/h6-7,9-10,12-13,21,25H,8,11,14-15H2,1-5H3/t21-/m1/s1

InChI key

COFVZFLCAOUMJT-OAQYLSRUSA-N

생화학적/생리학적 작용

TCS OX2 29 or TCS-OX2-29 is a potent and selective orexin 2 receptor (Ox2R, Ox2-R, Ox-2-R) antagonist (IC50 = 40 nM/Ox2R, >10 μM/Ox1R) with little potency toward 50 other receptors, ion channels, and transporters tested (<30% inhibition at 10 μM). TCS OX2 29 is widely used for elucidating various physiological functions mediated by Ox2R both in cultures and in mice and rats in vivo.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

Masaaki Hirose et al.
Bioorganic & medicinal chemistry letters, 13(24), 4497-4499 (2003-12-04)
The identification of potent and selective orexin-2 receptor (OX(2)R) antagonists is described based on the modification of N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline analogue 1, recently discovered during high throughput screening (HTS). Substitution of an acyl group in 1 with tert-Leucine (tert-Leu), and introduction
Li-Wei Tung et al.
Nature communications, 7, 12199-12199 (2016-07-23)
Orexins are associated with drug relapse in rodents. Here, we show that acute restraint stress in mice activates lateral hypothalamic (LH) orexin neurons, increases levels of orexin A and 2-arachidonoylglycerol (2-AG) in the ventral tegmental area (VTA), and reinstates extinguished

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