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Merck
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SML2807

Sigma-Aldrich

JP4-039

≥98% (HPLC)

동의어(들):

4-[[(3E,5S)-5-[[(1,1-Dimethylethoxy)carbonyl]amino]-7-methyl-1-oxo-3-octen-1-yl]amino]-2,2,6,6-tetramethyl-1-piperidinyloxy, JP 4-039

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200 MG
CA$560.32

CA$560.32

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모든 사진(1)

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200 MG
CA$560.32

About This Item

실험식(Hill 표기법):
C23H42N3O4
CAS Number:
1205492-16-5
Molecular Weight:
424.60
UNSPSC 코드:
12352200
NACRES:
NA.77

CA$560.32

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Quality Level

100

분석

≥98% (HPLC)

양식

powder

색상

faint yellow to dark orange

solubility

DMSO: 2 mg/mL, clear

저장 온도

−20°C

SMILES string

O=C(C/C=C/[C@@H](NC(OC(C)(C)C)=O)CC(C)C)NC1CC(C)(C)N([O])C(C)(C)C1

InChI

1S/C23H42N3O4/c1-16(2)13-17(25-20(28)30-21(3,4)5)11-10-12-19(27)24-18-14-22(6,7)26(29)23(8,9)15-18/h10-11,16-18H,12-15H2,1-9H3,(H,24,27)(H,25,28)/b11-10+/t17-/m1/s1

InChI key

AJHRJWQXDNEJAG-SXSDINLZSA-N

유사한 품목 비교

전체 비교 보기

차이점 표시

1 of 4

이 품목
MAK133MAK113CS0012
ADP/ATP Ratio Assay Kit sufficient for 100 tests (bioluminescent)

MAK135

ADP/ATP Ratio Assay Kit

ADP Assay Kit sufficient for 100 assays (bioluminescent)

MAK133

ADP Assay Kit

ATPase/GTPase Activity Assay Kit sufficient for 200 colorimetric tests

MAK113

ATPase/GTPase Activity Assay Kit

ATP Bioluminescence Kit Sufficient for 200 tests

CS0012

ATP Bioluminescence Kit

detection method

chemiluminescent

detection method

chemiluminescent

detection method

colorimetric

detection method

-

usage

sufficient for 100 tests (bioluminescent)

usage

sufficient for 100 assays (bioluminescent)

usage

sufficient for 200 colorimetric tests

usage

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

application(s)

pharmaceutical

application(s)

-

application(s)

-

application(s)

-

relevant disease(s)

cancer

relevant disease(s)

hematological disorder; cancer

relevant disease(s)

cancer

relevant disease(s)

-

생화학적/생리학적 작용

JP4-039 is an electron-/reactive oxygen species (ROS)-scavenging GS-nitroxide composed of 4-amino-TEMPO and a truncated gramicidin S (GS) mitochrondria-targeting sequence. JP4-039 is a superior irradiation mitigator than XJB-5-131 (33% vs. 20% mice survial rate on day 35 with respective compound; 23.6 μmol/kg iv. 24 hr post 9.5 Gy whole body irradiation), while displaying weaker anti-ferroptotic potency (EC50 = 3.58 μM/1.27 μM against 10 μM erastin-/2 μM RSL3-induced HT-1080 ferroptosis vs. 114 nM/68 nM with XJB-5-131) due to lower lipophilicity & mitochondria enrichment. Typical dosing range: 40 nM-10 μM in cultures and 10-20 mg/kg in mice (im., ip., iv.) in vivo.
Mitochondrial-targeted reactive oxygen species (ROS)-scavenging gramicidin S (GS)-nitroxide with in vitro and in vivo efficacy against irradiation-induced damage.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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    문서 라이브러리 방문

    Susan M Daly et al.
    Langmuir : the ACS journal of surfaces and colloids, 22(3), 1215-1222 (2006-01-25)
    We formed monolayers and black lipid membranes (BLMs) of photopolymerizable lipids mixed with the channel-forming protein gramicidin A to evaluate their miscibility and the potential for improved stability of the BLM scaffold through polymerization. Analyses of surface pressure vs area
    Grzegorz Godlewski et al.
    The Journal of pharmacology and experimental therapeutics, 328(1), 351-361 (2008-10-17)
    The novel endocannabinoid-like lipid N-arachidonoyl L-serine (ARA-S) causes vasodilation through both endothelium-dependent and -independent mechanisms. We have analyzed the vasorelaxant effect of ARA-S in isolated vascular preparations and its effects on Ca(2+)-activated K(+) currents in human embryonic kidney cells stably
    S Punnamaraju et al.
    Langmuir : the ACS journal of surfaces and colloids, 28(20), 7657-7664 (2012-05-03)
    A combination of nonpolymerizable phospholipids (DPPC or DPhPC) and a smaller amount of cross-linking photopolymerizable phospholipids (23:2 DiynePC) is incorporated in an unsupported artificial lipid bilayer formed using the droplet interface bilayer (DIB) approach. The DIB is formed by contacting

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