G7048

Proguanil hydrochloride

≥95% (HPLC)

• 동의어(들): Chlorguanide, N¹-(4-Chlorophenyl)-N⁵-isopropylbiguanide
• 실험식(Hill 표기법): C₁₁H₁₆ClN₅·HCl
• CAS Number: 637-32-1
• Molecular Weight: 290.19
• EC Number: 211-283-7
• MDL number: MFCD01732193
• UNSPSC 코드: 51101906
• PubChem Substance ID: 329799959
• NACRES: NA.77

속성

• 분석: ≥95% (HPLC)
• 형태: solid
• 저장 조건: desiccated
• solubility: acetonitrile: water: ~1 mg/mL (60/40)
• 주관자: AstraZeneca
• 저장 온도: 2-8°C
• SMILES string: Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1
• InChI: 1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H
• InChI key: SARMGXPVOFNNNG-UHFFFAOYSA-N

설명

애플리케이션

Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.

생화학적/생리학적 작용

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

특징 및 장점

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable