추천 제품
Quality Level
분석
≥98% (HPLC)
형태
powder
색상
white to beige
solubility
DMSO: 20 mg/mL, clear
저장 온도
−20°C
SMILES string
O=C1NC2=CC(C(F)(F)F)=CC=C2[C@@]1(C3=CC(Cl)=CC=C3OC)F
InChI
1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
InChI key
ULYONBAOIMCNEH-HNNXBMFYSA-N
유전자 정보
human ... KCNMA1(3778) , KCNQ2(3785) , KCNQ3(3786) , KCNQ4(9132) , KCNQ5(56479)
애플리케이션
BMS 204352 has been used in drug administration.
생화학적/생리학적 작용
BMS 204352 (MaxiPost [(3S)-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one)] is used to treat ischemic stroke. It also acts as an activator of KNCQ4 (KQT-like subfamily, member 4) and KCNQ5 (KQT-like subfamily, member 5) with equal potency.
BMS 204352 is a potassium channel modulator. Originally developed as a potent opener of large-conductance, calcium-activated (Maxi-K, KCa1.1, BK) potassium channels, BMS 204352 also acts as a positive modulator at Kv7 (KCNQ) channels.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Mohammad Al-Mahdi Al-Karagholi et al.
Cephalalgia : an international journal of headache, 40(11), 1145-1154 (2020-08-28)
Preclinical data implicate large conductance calcium-activated potassium (BKCa) channels in the pathogenesis of headache and migraine, but the exact role of these channels is still unknown. Here, we investigated whether opening of BKCa channels would cause headache and vascular effects
Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule.
Hebert B, et al.
Orphanet Journal of Rare Diseases, 9(1), 124-124 (2014)
CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory.
Song T, et al.
PLoS Genetics, 14(1), e1007165-e1007165 (2018)
A small molecule activator of KCNQ2 and KCNQ4 channels.
Probe Reports from the NIH Molecular Libraries Program (2013)
METABOLISM, PHARMACOKINETICS, AND PROTEIN COVALENT BINDING OF RADIOLABELED MAXIPOST IN HUMANS.
Zhang D, et al.
Drug Metabolism and Disposition, 33(1), 83-93 (2004)
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